The MKRN1 gene and its putative association with human ageing

Cell Senescence Entries for MKRN1

Cell Types: Colon cancer
Cell Lines: HCT116
Cancer Cell?: Yes
Method: Knockdown
Type of senescence: Unclear
Senescence Effect: Inhibits
Primary Reference: Lee et al. (2009) Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. EMBO J 28(14)2100-13 (PubMed)

HGNC symbol: MKRN1
Aliases: RNF61
Common name: makorin ring finger protein 1
Entrez Id: 23608
Description: This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014].

Gene Ontology

Process:

GO:16567; protein ubiquitination
GO:209; protein polyubiquitination

Cellular component:

GO:5829; cytosol
GO:5575; cellular_component

Function:

GO:3723; RNA binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:5515; protein binding
GO:61630; ubiquitin protein ligase activity

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