Cell Senescence Entries for MMP9

Cell Types
Medulloblastoma
Cell Lines
DAOY
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Rao et al. (2007) MMP-9 short interfering RNA induced senescence resulting in inhibition of medulloblastoma growth via p16(INK4a) and mitogen-activated protein kinase pathway. Cancer Res 67(10)4956-64 (PubMed)

MMP9 Gene Information

HGNC symbol
MMP9 
Aliases
CLG4B 
Common name
matrix metallopeptidase 9 
Entrez Id
4318
Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008].

MMP9 Ontologies

Gene Ontology
Process: GO:1904707; positive regulation of vascular associated smooth muscle cell proliferation
GO:6508; proteolysis
GO:30574; collagen catabolic process
GO:1503; ossification
GO:30198; extracellular matrix organization
GO:50900; leukocyte migration
GO:1904645; response to amyloid-beta
GO:30335; positive regulation of cell migration
GO:22617; extracellular matrix disassembly
GO:34614; cellular response to reactive oxygen species
GO:71276; cellular response to cadmium ion
GO:48013; ephrin receptor signaling pathway
GO:1934; positive regulation of protein phosphorylation
GO:43066; negative regulation of apoptotic process
GO:71492; cellular response to UV-A
GO:35987; endodermal cell differentiation
GO:150077; regulation of neuroinflammatory response
GO:30225; macrophage differentiation
GO:1501; skeletal system development
GO:7566; embryo implantation
GO:43065; positive regulation of apoptotic process
GO:43388; positive regulation of DNA binding
GO:45742; positive regulation of epidermal growth factor receptor signaling pathway
GO:51549; positive regulation of keratinocyte migration
GO:90200; positive regulation of release of cytochrome c from mitochondria
GO:1900122; positive regulation of receptor binding
GO:2000697; negative regulation of epithelial cell differentiation involved in kidney development
GO:2001243; negative regulation of intrinsic apoptotic signaling pathway
GO:2001258; negative regulation of cation channel activity
GO:2001268; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Cellular component: GO:5576; extracellular region
GO:5615; extracellular space
GO:31012; extracellular matrix
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
GO:1904813; ficolin-1-rich granule lumen
GO:1904724; tertiary granule lumen
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:5515; protein binding
GO:4222; metalloendopeptidase activity
GO:8237; metallopeptidase activity
GO:42802; identical protein binding
GO:4252; serine-type endopeptidase activity
GO:5518; collagen binding
GO:4175; endopeptidase activity
Hide GO terms

Homologs of MMP9 in Model Organisms

Danio rerio
mmp9
Mus musculus
Mmp9
Rattus norvegicus
Mmp9

External links

OMIM
120361
Ensembl
ENSG00000100985
Entrez Gene
4318
UniGene
297413
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MMP9
GeneCards
MMP9