Cell Senescence Entries for MRTFB
- Cell Types
- Liver cancer
- Cell Lines
- HuH6, Huh7
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Hampl et al. (2014) Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence. EMBO Mol Med 5(9)1367-82 (PubMed)
MRTFB Gene Information
- HGNC symbol
- MRTFB
- Aliases
- FLJ31823; MKL2; MRTF-B
- Common name
- myocardin related transcription factor B
- Entrez Id
- 57496
- Description
MRTFB Ontologies
- Gene Ontology
-
Process: GO:30154; cell differentiation
GO:7517; muscle organ development
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:51145; smooth muscle cell differentiation
GO:45844; positive regulation of striated muscle tissue development
GO:43086; negative regulation of catalytic activity
Cellular component: GO:5634; nucleus
Hide GO termsFunction: GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:45296; cadherin binding
GO:3779; actin binding
GO:4864; protein phosphatase inhibitor activity
Homologs of MRTFB in Model Organisms
- Danio rerio
- wu:fl04e06
- Mus musculus
- Mkl2
- Rattus norvegicus
- RGD1560833
External links
- OMIM
- 609463
- Ensembl
- ENSG00000186260
- Entrez Gene
- 57496
- UniGene
- 683854
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- MRTFB
- GeneCards
- MRTFB