Cell Senescence Entries for MTDH

Cell Types
Human prostate cancer cells
Cell Lines
C42B, LNCaP
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Draz et al. (2018) Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK). Cell Signal 40(2)172-182 (PubMed)

MTDH Gene Information

HGNC symbol
MTDH 
Aliases
3D3; AEG-1; LYRIC 
Common name
metadherin 
Entrez Id
92140
Description

MTDH Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:45893; positive regulation of transcription, DNA-templated
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:122; negative regulation of transcription by RNA polymerase II
GO:45766; positive regulation of angiogenesis
GO:6357; regulation of transcription by RNA polymerase II
GO:51897; positive regulation of protein kinase B signaling
GO:10508; positive regulation of autophagy
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:31663; lipopolysaccharide-mediated signaling pathway
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:1650; fibrillar center
GO:30054; cell junction
GO:16324; apical plasma membrane
GO:5730; nucleolus
GO:31965; nuclear membrane
GO:48471; perinuclear region of cytoplasm
GO:5923; bicellular tight junction
GO:16604; nuclear body
GO:46581; intercellular canaliculus
Function: GO:3723; RNA binding
GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:3712; transcription coregulator activity
GO:51059; NF-kappaB binding
GO:3725; double-stranded RNA binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
Hide GO terms

Homologs of MTDH in Model Organisms

Danio rerio
mtdha
Mus musculus
Mtdh
Rattus norvegicus
Mtdh

External links

OMIM
610323
Ensembl
ENSG00000147649
Entrez Gene
92140
UniGene
377155
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MTDH
GeneCards
MTDH