Cell Senescence Entries for MYC

Cell Types
Fibroblast
Cell Lines
LF1
Cancer Cell?
No
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Guney et al. (2006) Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). Proc Natl Acad Sci U S A 103(10)3645-50 (PubMed)

MYC Gene Information

HGNC symbol
MYC 
Aliases
bHLHe39; c-Myc; MYCC 
Common name
MYC proto-oncogene, bHLH transcription factor 
Entrez Id
4609
Description
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017].

MYC Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:8150; biological_process
GO:45727; positive regulation of translation
GO:43066; negative regulation of apoptotic process
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:6879; cellular iron ion homeostasis
GO:51276; chromosome organization
GO:6338; chromatin remodeling
GO:9410; response to xenobiotic stimulus
GO:165; MAPK cascade
GO:6357; regulation of transcription by RNA polymerase II
GO:15671; oxygen transport
GO:10332; response to gamma radiation
GO:71466; cellular response to xenobiotic stimulus
GO:8284; positive regulation of cell population proliferation
GO:10564; regulation of cell cycle process
GO:43280; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:82; G1/S transition of mitotic cell cycle
GO:10628; positive regulation of gene expression
GO:51973; positive regulation of telomerase activity
GO:48146; positive regulation of fibroblast proliferation
GO:34644; cellular response to UV
GO:10468; regulation of gene expression
GO:50679; positive regulation of epithelial cell proliferation
GO:2053; positive regulation of mesenchymal cell proliferation
GO:1904672; regulation of somatic stem cell population maintenance
GO:51782; negative regulation of cell division
GO:71456; cellular response to hypoxia
GO:1658; branching involved in ureteric bud morphogenesis
GO:6112; energy reserve metabolic process
GO:32204; regulation of telomere maintenance
GO:32873; negative regulation of stress-activated MAPK cascade
GO:32986; protein-DNA complex disassembly
GO:44346; fibroblast apoptotic process
GO:45656; negative regulation of monocyte differentiation
GO:48147; negative regulation of fibroblast proliferation
GO:70371; ERK1 and ERK2 cascade
GO:70848; response to growth factor
GO:90096; positive regulation of metanephric cap mesenchymal cell proliferation
GO:1902255; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1905643; positive regulation of DNA methylation
GO:2000573; positive regulation of DNA biosynthetic process
GO:2001022; positive regulation of response to DNA damage stimulus
Cellular component: GO:5654; nucleoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5791; rough endoplasmic reticulum
GO:5635; nuclear envelope
GO:44195; nucleoplasmic reticulum
GO:5730; nucleolus
GO:5634; nucleus
GO:32991; protein-containing complex
GO:5739; mitochondrion
GO:785; chromatin
GO:90571; RNA polymerase II transcription repressor complex
GO:71943; Myc-Max complex
Function: GO:3700; DNA-binding transcription factor activity
GO:3729; mRNA binding
GO:5515; protein binding
GO:71074; eukaryotic initiation factor eIF2 binding
GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:70888; E-box binding
GO:1221; transcription coregulator binding
GO:44877; protein-containing complex binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:1046; core promoter sequence-specific DNA binding
Hide GO terms

Homologs of MYC in Model Organisms

Danio rerio
myca
Mus musculus
Myc
Rattus norvegicus
Myc

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Myc
GenAge human genes
  • This gene is present as MYC

External links

OMIM
190080
Ensembl
ENSG00000136997
Entrez Gene
4609
UniGene
202453
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MYC
GeneCards
MYC