Cell Senescence Entries for MYD88

Cell Types
Breast cancer, Melanoma, Prostate cancer
Cell Lines
M628, MCF-7, PC-3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Ye et al. (2015) TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence. EMBO Mol Med 6(10)1294-311 (PubMed)

MYD88 Gene Information

HGNC symbol
MYD88 
Aliases
 
Common name
MYD88 innate immune signal transduction adaptor 
Entrez Id
4615
Description
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].

MYD88 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:6954; inflammatory response
GO:2755; MyD88-dependent toll-like receptor signaling pathway
GO:50830; defense response to Gram-positive bacterium
GO:6909; phagocytosis
GO:8063; Toll signaling pathway
GO:32731; positive regulation of interleukin-1 beta production
GO:71260; cellular response to mechanical stimulus
GO:1900227; positive regulation of NLRP3 inflammasome complex assembly
GO:10628; positive regulation of gene expression
GO:32755; positive regulation of interleukin-6 production
GO:32757; positive regulation of interleukin-8 production
GO:71222; cellular response to lipopolysaccharide
GO:140052; cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900017; positive regulation of cytokine production involved in inflammatory response
GO:7166; cell surface receptor signaling pathway
GO:70555; response to interleukin-1
GO:42742; defense response to bacterium
GO:50727; regulation of inflammatory response
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:60337; type I interferon signaling pathway
GO:32747; positive regulation of interleukin-23 production
GO:32740; positive regulation of interleukin-17 production
GO:70935; 3'-UTR-mediated mRNA stabilization
GO:32481; positive regulation of type I interferon production
GO:6915; apoptotic process
GO:34158; toll-like receptor 8 signaling pathway
GO:42832; defense response to protozoan
GO:2238; response to molecule of fungal origin
GO:2269; leukocyte activation involved in inflammatory response
GO:2283; neutrophil activation involved in immune response
GO:7254; JNK cascade
GO:9615; response to virus
GO:9682; induced systemic resistance
GO:10468; regulation of gene expression
GO:16064; immunoglobulin mediated immune response
GO:19221; cytokine-mediated signaling pathway
GO:31663; lipopolysaccharide-mediated signaling pathway
GO:32494; response to peptidoglycan
GO:32496; response to lipopolysaccharide
GO:32675; regulation of interleukin-6 production
GO:32680; regulation of tumor necrosis factor production
GO:32722; positive regulation of chemokine production
GO:32760; positive regulation of tumor necrosis factor production
GO:42127; regulation of cell population proliferation
GO:46330; positive regulation of JNK cascade
GO:48661; positive regulation of smooth muscle cell proliferation
GO:50671; positive regulation of lymphocyte proliferation
GO:70498; interleukin-1-mediated signaling pathway
GO:70944; neutrophil-mediated killing of bacterium
GO:90557; establishment of endothelial intestinal barrier
GO:1902622; regulation of neutrophil migration
GO:2000338; regulation of chemokine (C-X-C motif) ligand 1 production
GO:2000341; regulation of chemokine (C-X-C motif) ligand 2 production
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5886; plasma membrane
GO:5829; cytosol
GO:10008; endosome membrane
GO:14069; postsynaptic density
GO:32991; protein-containing complex
Function: GO:5515; protein binding
GO:3953; NAD+ nucleosidase activity
GO:42802; identical protein binding
GO:70976; TIR domain binding
GO:43621; protein self-association
GO:5123; death receptor binding
GO:35325; Toll-like receptor binding
GO:5102; signaling receptor binding
GO:5121; Toll binding
GO:5149; interleukin-1 receptor binding
Hide GO terms

Homologs of MYD88 in Model Organisms

Danio rerio
myd88
Drosophila melanogaster
Myd88
Mus musculus
Myd88
Rattus norvegicus
Myd88

External links

OMIM
602170
Ensembl
ENSG00000172936
Entrez Gene
4615
UniGene
82116
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MYD88
GeneCards
MYD88