Cell Senescence Entries for MYLK

Cell Types
Embryonic kidney, Retinal pigment epithelial
Cell Lines
HEK293T, HTERT-RPE1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lahtela et al. (2013) A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle 12(4)625-34 (PubMed)

MYLK Gene Information

HGNC symbol
MYLK 
Aliases
MLCK; MLCK1; MYLK1; smMLCK 
Common name
myosin light chain kinase 
Entrez Id
4638
Description
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008].

MYLK Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:30335; positive regulation of cell migration
GO:51928; positive regulation of calcium ion transport
GO:6939; smooth muscle contraction
GO:90303; positive regulation of wound healing
GO:32060; bleb assembly
GO:71476; cellular hypotonic response
GO:14820; tonic smooth muscle contraction
GO:60414; aorta smooth muscle tissue morphogenesis
Cellular component: GO:5737; cytoplasm
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:42995; cell projection
GO:15629; actin cytoskeleton
GO:30027; lamellipodium
GO:32154; cleavage furrow
GO:5829; cytosol
GO:1725; stress fiber
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:3779; actin binding
GO:5515; protein binding
GO:5516; calmodulin binding
GO:4687; myosin light chain kinase activity
Hide GO terms

Homologs of MYLK in Model Organisms

Danio rerio
mylkb
Mus musculus
Mylk
Rattus norvegicus
Mylk

In other databases

CellAge gene expression
  • This gene is present as MYLK

External links

OMIM
600922
Ensembl
ENSG00000065534
Entrez Gene
4638
UniGene
477375
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MYLK
GeneCards
MYLK