Cell Senescence Entries for NACC1

Cell Types
Ovarian cancer
Cell Lines
SKOV3, TOV-21G
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Nakayama et al. (2020) Nucleus accumbens-1/GADD45GIP1 axis mediates cisplatin resistance through cellular senescence in ovarian cancer. Oncol Lett 13(6)4713-4719 (PubMed)

NACC1 Gene Information

HGNC symbol
NACC1 
Aliases
BEND8; BTBD14B; BTBD30; NAC-1; NAC1 
Common name
nucleus accumbens associated 1 
Entrez Id
112939
Description
This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012].

NACC1 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:8284; positive regulation of cell population proliferation
GO:122; negative regulation of transcription by RNA polymerase II
GO:6357; regulation of transcription by RNA polymerase II
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:30054; cell junction
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:42826; histone deacetylase binding
Hide GO terms

Homologs of NACC1 in Model Organisms

Danio rerio
LOC572093
Mus musculus
Nacc1
Rattus norvegicus
Nacc1

External links

OMIM
610672
Ensembl
ENSG00000160877
Entrez Gene
112939
UniGene
531614
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NACC1
GeneCards
NACC1