Cell Senescence Entries for NAMPT

Cell Types
Vascular smooth muscle
Cell Lines
HITC6, Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
van der Veer et al. (2007) Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. J Biol Chem 282(15)10841-5 (PubMed)

NAMPT Gene Information

HGNC symbol
NAMPT 
Aliases
PBEF; PBEF1 
Common name
nicotinamide phosphoribosyltransferase 
Entrez Id
10135
Description
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011].

NAMPT Ontologies

Gene Ontology
Process: GO:9435; NAD biosynthetic process
GO:7165; signal transduction
GO:48511; rhythmic process
GO:19363; pyridine nucleotide biosynthetic process
GO:7623; circadian rhythm
GO:32922; circadian regulation of gene expression
GO:45944; positive regulation of transcription by RNA polymerase II
GO:7267; cell-cell signaling
GO:51770; positive regulation of nitric-oxide synthase biosynthetic process
GO:8284; positive regulation of cell population proliferation
GO:34356; NAD biosynthesis via nicotinamide riboside salvage pathway
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5576; extracellular region
GO:5615; extracellular space
GO:30054; cell junction
GO:5829; cytosol
GO:70062; extracellular exosome
Function: GO:3824; catalytic activity
GO:4514; nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:16740; transferase activity
GO:16757; glycosyltransferase activity
GO:5515; protein binding
GO:5125; cytokine activity
GO:42802; identical protein binding
GO:47280; nicotinamide phosphoribosyltransferase activity
Hide GO terms

Homologs of NAMPT in Model Organisms

Mus musculus
Nampt
Rattus norvegicus
Nampt

External links

OMIM
608764
Ensembl
ENSG00000105835
Entrez Gene
10135
UniGene
489615
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NAMPT
GeneCards
NAMPT