Cell Senescence Entries for NANOG

Cell Types
Dermal fibroblast
Cell Lines
Primary cell
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Münst et al. (2016) Nanog induces suppression of senescence through downregulation of p27KIP1 expression. J Cell Sci 129(5)912-20 (PubMed)

NANOG Gene Information

HGNC symbol
NANOG 
Aliases
FLJ12581; FLJ40451 
Common name
Nanog homeobox 
Entrez Id
79923
Description
The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].

NANOG Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:10468; regulation of gene expression
GO:122; negative regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:19827; stem cell population maintenance
GO:35019; somatic stem cell population maintenance
GO:1714; endodermal cell fate specification
GO:30154; cell differentiation
GO:45595; regulation of cell differentiation
GO:2000648; positive regulation of stem cell proliferation
Cellular component: GO:5634; nucleus
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:785; chromatin
GO:5730; nucleolus
Function: GO:3677; DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:3700; DNA-binding transcription factor activity
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
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Homologs of NANOG in Model Organisms

No homologs found

External links

OMIM
607937
Ensembl
ENSG00000111704
Entrez Gene
79923
UniGene
635882
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NANOG
GeneCards
NANOG