Cell Senescence Entries for NBN

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Khongkow et al. (2014) FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance. Oncogene 33(32)4144-55 (PubMed)

NBN Gene Information

HGNC symbol
NBN 
Aliases
AT-V1; AT-V2; ATV; NBS; NBS1 
Common name
nibrin 
Entrez Id
4683
Description
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008].

NBN Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:723; telomere maintenance
GO:6302; double-strand break repair
GO:51321; meiotic cell cycle
GO:51726; regulation of cell cycle
GO:7095; mitotic G2 DNA damage checkpoint signaling
GO:30330; DNA damage response, signal transduction by p53 class mediator
GO:724; double-strand break repair via homologous recombination
GO:90656; t-circle formation
GO:90737; telomere maintenance via telomere trimming
GO:77; DNA damage checkpoint signaling
GO:1701; in utero embryonic development
GO:1832; blastocyst growth
GO:8283; cell population proliferation
GO:30174; regulation of DNA-dependent DNA replication initiation
GO:31860; telomeric 3' overhang formation
GO:31954; positive regulation of protein autophosphorylation
GO:32206; positive regulation of telomere maintenance
GO:32508; DNA duplex unwinding
GO:33674; positive regulation of kinase activity
GO:45190; isotype switching
GO:50885; neuromuscular process controlling balance
GO:97193; intrinsic apoptotic signaling pathway
GO:1904354; negative regulation of telomere capping
GO:44818; mitotic G2/M transition checkpoint
GO:729; DNA double-strand break processing
GO:35825; homologous recombination
GO:110025; DNA strand resection involved in replication fork processing
GO:7093; mitotic cell cycle checkpoint signaling
GO:50896; response to stimulus
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5694; chromosome
GO:30870; Mre11 complex
GO:16605; PML body
GO:5654; nucleoplasm
GO:5829; cytosol
GO:35861; site of double-strand break
GO:5730; nucleolus
GO:70533; BRCA1-C complex
GO:5657; replication fork
GO:42405; nuclear inclusion body
GO:98687; chromosomal region
GO:43229; intracellular organelle
Function: GO:5515; protein binding
GO:3684; damaged DNA binding
GO:140297; DNA-binding transcription factor binding
GO:47485; protein N-terminus binding
Hide GO terms

Homologs of NBN in Model Organisms

Danio rerio
nbn
Mus musculus
Nbn
Rattus norvegicus
Nbn

In other databases

GenAge human genes
  • This gene is present as NBN
LongevityMap
  • This gene is present as NBN

External links

OMIM
602667
Ensembl
ENSG00000104320
Entrez Gene
4683
UniGene
492208
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NBN
GeneCards
NBN