Cell Senescence Entries for NBR1

Cell Types
Breast cancer, Kidney cancer, Lung fibroblast
Cell Lines
Caki-1, MCF-7, MRC-5
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2019) The p38-activated ER stress-ATF6α axis mediates cellular senescence. FASEB J 33(2)2422-2434 (PubMed)

NBR1 Gene Information

HGNC symbol
NBR1 
Aliases
1A1-3B; CA125; KIAA0049; M17S2 
Common name
NBR1 autophagy cargo receptor 
Entrez Id
4077
Description
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014].

NBR1 Ontologies

Gene Ontology
Process: GO:16236; macroautophagy
GO:30500; regulation of bone mineralization
GO:45668; negative regulation of osteoblast differentiation
GO:32872; regulation of stress-activated MAPK cascade
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:31410; cytoplasmic vesicle
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5770; late endosome
GO:5829; cytosol
GO:16604; nuclear body
GO:5764; lysosome
GO:407; phagophore assembly site
GO:5776; autophagosome
GO:43235; receptor complex
GO:31430; M band
GO:5739; mitochondrion
GO:5778; peroxisomal membrane
GO:5758; mitochondrial intermembrane space
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:5515; protein binding
GO:43130; ubiquitin binding
GO:51019; mitogen-activated protein kinase binding
Hide GO terms

Homologs of NBR1 in Model Organisms

Danio rerio
nbr1
Mus musculus
Nbr1
Rattus norvegicus
Nbr1

External links

OMIM
166945
Ensembl
ENSG00000188554
Entrez Gene
4077
UniGene
708158
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NBR1
GeneCards
NBR1