Cell Senescence Entries for NCAPG2

Cell Types
Retinal pigment epithelial
Cell Lines
RPE-1
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Nishide et al. (2016) Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. PLoS Genet 10(12)e1004847 (PubMed)

NCAPG2 Gene Information

HGNC symbol
NCAPG2 
Aliases
CAP-G2; FLJ20311; hCAP-G2; LUZP5; MTB 
Common name
non-SMC condensin II complex subunit G2 
Entrez Id
54892
Description
This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].

NCAPG2 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:50790; regulation of catalytic activity
GO:51301; cell division
GO:30261; chromosome condensation
GO:2000272; negative regulation of signaling receptor activity
GO:70; mitotic sister chromatid segregation
GO:1905821; positive regulation of chromosome condensation
GO:61099; negative regulation of protein tyrosine kinase activity
GO:31063; regulation of histone deacetylation
GO:1833; inner cell mass cell proliferation
GO:6366; transcription by RNA polymerase II
GO:30218; erythrocyte differentiation
GO:51984; positive regulation of chromosome segregation
GO:1905820; positive regulation of chromosome separation
Cellular component: GO:5634; nucleus
GO:16607; nuclear speck
GO:16020; membrane
GO:5654; nucleoplasm
GO:796; condensin complex
GO:794; condensed nuclear chromosome
Function: GO:5515; protein binding
GO:35064; methylated histone binding
GO:8047; enzyme activator activity
GO:30293; transmembrane receptor protein tyrosine kinase inhibitor activity
GO:35033; histone deacetylase regulator activity
GO:43425; bHLH transcription factor binding
Hide GO terms

Homologs of NCAPG2 in Model Organisms

Danio rerio
ncapg2
Mus musculus
Ncapg2
Rattus norvegicus
Ncapg2

In other databases

CellAge gene expression
  • This gene is present as NCAPG2

External links

OMIM
608532
Ensembl
ENSG00000146918
Entrez Gene
54892
UniGene
18616
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NCAPG2
GeneCards
NCAPG2