Cell Senescence Entries for NEK1

Cell Types
Embryonic kidney, Retinal pigment epithelial
Cell Lines
HEK293T, HTERT-RPE1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lahtela et al. (2013) A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle 12(4)625-34 (PubMed)

NEK1 Gene Information

HGNC symbol
NEK1 
Aliases
KIAA1901; NY-REN-55 
Common name
NIMA related kinase 1 
Entrez Id
4750
Description
The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010].

NEK1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:18108; peptidyl-tyrosine phosphorylation
GO:51301; cell division
GO:60271; cilium assembly
GO:30030; cell projection organization
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
GO:34451; centriolar satellite
GO:5815; microtubule organizing center
GO:5813; centrosome
GO:242; pericentriolar material
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
GO:71889; 14-3-3 protein binding
Hide GO terms

Homologs of NEK1 in Model Organisms

Danio rerio
nek1
Mus musculus
Nek1
Rattus norvegicus
Nek1

External links

OMIM
604588
Ensembl
ENSG00000137601
Entrez Gene
4750
UniGene
481181
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NEK1
GeneCards
NEK1