Cell Senescence Entries for NEK2

Cell Types
Mammary fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Avelar et al. (2021) A multidimensional systems biology analysis of cellular senescence in aging and disease. Genome Biol 21(1)91 (PubMed)

NEK2 Gene Information

HGNC symbol
NEK2 
Aliases
NEK2A; NLK1; PPP1R111; RP67 
Common name
NIMA related kinase 2 
Entrez Id
4751
Description
This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011].

NEK2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:51301; cell division
GO:51321; meiotic cell cycle
GO:7059; chromosome segregation
GO:46777; protein autophosphorylation
GO:32212; positive regulation of telomere maintenance via telomerase
GO:51973; positive regulation of telomerase activity
GO:1904355; positive regulation of telomere capping
GO:7088; regulation of mitotic nuclear division
GO:46602; regulation of mitotic centrosome separation
GO:278; mitotic cell cycle
GO:51225; spindle assembly
GO:51988; regulation of attachment of spindle microtubules to kinetochore
GO:70; mitotic sister chromatid segregation
GO:1824; blastocyst development
GO:43392; negative regulation of DNA binding
GO:51299; centrosome separation
GO:90307; mitotic spindle assembly
GO:1903126; negative regulation of centriole-centriole cohesion
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5856; cytoskeleton
GO:5694; chromosome
GO:5813; centrosome
GO:5730; nucleolus
GO:5874; microtubule
GO:775; chromosome, centromeric region
GO:5815; microtubule organizing center
GO:776; kinetochore
GO:922; spindle pole
GO:5829; cytosol
GO:794; condensed nuclear chromosome
GO:30496; midbody
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:19903; protein phosphatase binding
Hide GO terms

Homologs of NEK2 in Model Organisms

Danio rerio
nek2
Drosophila melanogaster
Nek2
Mus musculus
Nek2
Rattus norvegicus
Nek2l1
Saccharomyces cerevisiae
KIN3
Schizosaccharomyces pombe
fin1

In other databases

CellAge gene expression
  • This gene is present as NEK2

External links

OMIM
604043
Ensembl
ENSG00000117650
Entrez Gene
4751
UniGene
153704
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NEK2
GeneCards
NEK2