Cell Senescence Entries for NEK6

Cell Types
Bladder cancer, Lung cancer
Cell Lines
EJ, NCI-H1299
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Jee et al. (2011) Nek6 overexpression antagonizes p53-induced senescence in human cancer cells. Cell Cycle 9(23)4703-10 (PubMed)

NEK6 Gene Information

HGNC symbol
NEK6 
Aliases
SID6-1512 
Common name
NIMA related kinase 6 
Entrez Id
10783
Description
The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

NEK6 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:51301; cell division
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:18105; peptidyl-serine phosphorylation
GO:7059; chromosome segregation
GO:46777; protein autophosphorylation
GO:7346; regulation of mitotic cell cycle
GO:2000772; regulation of cellular senescence
GO:51225; spindle assembly
GO:7077; mitotic nuclear membrane disassembly
GO:7052; mitotic spindle organization
GO:30071; regulation of mitotic metaphase/anaphase transition
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
GO:5874; microtubule
GO:34451; centriolar satellite
GO:5815; microtubule organizing center
GO:922; spindle pole
GO:5813; centrosome
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
GO:287; magnesium ion binding
GO:140297; DNA-binding transcription factor binding
GO:19901; protein kinase binding
GO:19894; kinesin binding
GO:1222; transcription corepressor binding
Hide GO terms

Homologs of NEK6 in Model Organisms

Caenorhabditis elegans
nekl-3
Mus musculus
Nek6
Rattus norvegicus
Nek6

External links

OMIM
604884
Ensembl
ENSG00000119408
Entrez Gene
10783
UniGene
197071
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NEK6
GeneCards
NEK6