Cell Senescence Entries for NF1

Cell Types
Melanocyte
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Larribere et al. (2016) NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based model. Pigment Cell Melanoma Res 28(4)407-16 (PubMed)

NF1 Gene Information

HGNC symbol
NF1 
Aliases
 
Common name
neurofibromin 1 
Entrez Id
4763
Description
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008].

NF1 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:43087; regulation of GTPase activity
GO:43547; positive regulation of GTPase activity
GO:7265; Ras protein signal transduction
GO:48147; negative regulation of fibroblast proliferation
GO:1937; negative regulation of endothelial cell proliferation
GO:165; MAPK cascade
GO:30336; negative regulation of cell migration
GO:43409; negative regulation of MAPK cascade
GO:1649; osteoblast differentiation
GO:1656; metanephros development
GO:1666; response to hypoxia
GO:1889; liver development
GO:1952; regulation of cell-matrix adhesion
GO:6469; negative regulation of protein kinase activity
GO:7154; cell communication
GO:7406; negative regulation of neuroblast proliferation
GO:7420; brain development
GO:7422; peripheral nervous system development
GO:7507; heart development
GO:8542; visual learning
GO:14044; Schwann cell development
GO:14065; phosphatidylinositol 3-kinase signaling
GO:21510; spinal cord development
GO:21897; forebrain astrocyte development
GO:21987; cerebral cortex development
GO:22011; myelination in peripheral nervous system
GO:30036; actin cytoskeleton organization
GO:30198; extracellular matrix organization
GO:30199; collagen fibril organization
GO:30325; adrenal gland development
GO:42060; wound healing
GO:43065; positive regulation of apoptotic process
GO:43407; negative regulation of MAP kinase activity
GO:43473; pigmentation
GO:43525; positive regulation of neuron apoptotic process
GO:43535; regulation of blood vessel endothelial cell migration
GO:45124; regulation of bone resorption
GO:45685; regulation of glial cell differentiation
GO:45762; positive regulation of adenylate cyclase activity
GO:45765; regulation of angiogenesis
GO:48485; sympathetic nervous system development
GO:48593; camera-type eye morphogenesis
GO:48715; negative regulation of oligodendrocyte differentiation
GO:48745; smooth muscle tissue development
GO:48844; artery morphogenesis
GO:48853; forebrain morphogenesis
GO:50890; cognition
GO:16525; negative regulation of angiogenesis
GO:8285; negative regulation of cell population proliferation
GO:30948; negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:38026; reelin-mediated signaling pathway
GO:1938; positive regulation of endothelial cell proliferation
GO:1953; negative regulation of cell-matrix adhesion
GO:7519; skeletal muscle tissue development
GO:8625; extrinsic apoptotic signaling pathway via death domain receptors
GO:10468; regulation of gene expression
GO:21764; amygdala development
GO:21915; neural tube development
GO:32228; regulation of synaptic transmission, GABAergic
GO:34605; cellular response to heat
GO:35021; negative regulation of Rac protein signal transduction
GO:42127; regulation of cell population proliferation
GO:42308; negative regulation of protein import into nucleus
GO:43408; regulation of MAPK cascade
GO:45671; negative regulation of osteoclast differentiation
GO:46580; negative regulation of Ras protein signal transduction
GO:46929; negative regulation of neurotransmitter secretion
GO:48169; regulation of long-term neuronal synaptic plasticity
GO:48712; negative regulation of astrocyte differentiation
GO:48820; hair follicle maturation
GO:61534; gamma-aminobutyric acid secretion, neurotransmission
GO:61535; glutamate secretion, neurotransmission
GO:98597; observational learning
GO:1900271; regulation of long-term synaptic potentiation
GO:2001241; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:1902531; regulation of intracellular signal transduction
Cellular component: GO:5634; nucleus
GO:16020; membrane
GO:98793; presynapse
GO:5730; nucleolus
GO:5829; cytosol
GO:5737; cytoplasm
GO:30424; axon
GO:30425; dendrite
GO:16021; integral component of membrane
Function: GO:5096; GTPase activator activity
GO:5515; protein binding
GO:8289; lipid binding
GO:8429; phosphatidylethanolamine binding
GO:31210; phosphatidylcholine binding
Hide GO terms

Homologs of NF1 in Model Organisms

Danio rerio
nf1b
Drosophila melanogaster
Nf1
Mus musculus
Nf1
Rattus norvegicus
Nf1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Nf1

External links

OMIM
613113
Ensembl
ENSG00000196712
Entrez Gene
4763
UniGene
113577
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NF1
GeneCards
NF1