Cell Senescence Entries for NF2

Cell Types
Foreskin fibroblast, Melanocyte
Cell Lines
BJ, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wajapeyee et al. (2008) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132(3)363-74 (PubMed)

NF2 Gene Information

HGNC symbol
NF2 
Aliases
ACN; BANF; merlin; merlin-1; SCH 
Common name
neurofibromin 2 
Entrez Id
4771
Description
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008].

NF2 Ontologies

Gene Ontology
Process: GO:51726; regulation of cell cycle
GO:42981; regulation of apoptotic process
GO:8285; negative regulation of cell population proliferation
GO:46426; negative regulation of receptor signaling pathway via JAK-STAT
GO:30036; actin cytoskeleton organization
GO:1953; negative regulation of cell-matrix adhesion
GO:14010; Schwann cell proliferation
GO:14013; regulation of gliogenesis
GO:22408; negative regulation of cell-cell adhesion
GO:30336; negative regulation of cell migration
GO:35330; regulation of hippo signaling
GO:42532; negative regulation of tyrosine phosphorylation of STAT protein
GO:51496; positive regulation of stress fiber assembly
GO:1707; mesoderm formation
GO:6469; negative regulation of protein kinase activity
GO:7398; ectoderm development
GO:7420; brain development
GO:21766; hippocampus development
GO:31647; regulation of protein stability
GO:42127; regulation of cell population proliferation
GO:42475; odontogenesis of dentin-containing tooth
GO:43409; negative regulation of MAPK cascade
GO:45216; cell-cell junction organization
GO:45597; positive regulation of cell differentiation
GO:50767; regulation of neurogenesis
GO:70306; lens fiber cell differentiation
GO:72091; regulation of stem cell proliferation
GO:1900180; regulation of protein localization to nucleus
GO:2000177; regulation of neural precursor cell proliferation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:42995; cell projection
GO:48471; perinuclear region of cytoplasm
GO:32587; ruffle membrane
GO:5912; adherens junction
GO:5769; early endosome
GO:31527; filopodium membrane
GO:45177; apical part of cell
GO:5730; nucleolus
GO:71944; cell periphery
GO:110165; cellular anatomical entity
GO:1726; ruffle
GO:30027; lamellipodium
GO:30175; filopodium
GO:30864; cortical actin cytoskeleton
GO:32154; cleavage furrow
GO:43005; neuron projection
GO:44297; cell body
Function: GO:3779; actin binding
GO:5515; protein binding
GO:8092; cytoskeletal protein binding
GO:5178; integrin binding
Hide GO terms

Homologs of NF2 in Model Organisms

Danio rerio
nf2a
Drosophila melanogaster
Mer
Mus musculus
Nf2
Rattus norvegicus
Nf2

External links

OMIM
607379
Ensembl
ENSG00000186575
Entrez Gene
4771
UniGene
187898
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NF2
GeneCards
NF2