Cell Senescence Entries for NFE2L2

Cell Types
Lung fibroblast
Cell Lines
HFL1
Cancer Cell?
No
Method
Knockout
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kapeta et al. (2010) Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts. J Biol Chem 285(11)8171-84 (PubMed)

NFE2L2 Gene Information

HGNC symbol
NFE2L2 
Aliases
NRF2 
Common name
nuclear factor, erythroid 2 like 2 
Entrez Id
4780
Description
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015].

NFE2L2 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:16567; protein ubiquitination
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45088; regulation of innate immune response
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:6357; regulation of transcription by RNA polymerase II
GO:34599; cellular response to oxidative stress
GO:10628; positive regulation of gene expression
GO:45454; cell redox homeostasis
GO:10499; proteasomal ubiquitin-independent protein catabolic process
GO:1903206; negative regulation of hydrogen peroxide-induced cell death
GO:71498; cellular response to fluid shear stress
GO:2000352; negative regulation of endothelial cell apoptotic process
GO:71499; cellular response to laminar fluid shear stress
GO:1903071; positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1902176; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:71356; cellular response to tumor necrosis factor
GO:36499; PERK-mediated unfolded protein response
GO:70301; cellular response to hydrogen peroxide
GO:61419; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:36003; positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:30968; endoplasmic reticulum unfolded protein response
GO:140467; integrated stress response signaling
GO:6954; inflammatory response
GO:7568; aging
GO:9410; response to xenobiotic stimulus
GO:10226; response to lithium ion
GO:10667; negative regulation of cardiac muscle cell apoptotic process
GO:10976; positive regulation of neuron projection development
GO:30194; positive regulation of blood coagulation
GO:34976; response to endoplasmic reticulum stress
GO:36091; positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:42149; cellular response to glucose starvation
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:45766; positive regulation of angiogenesis
GO:45893; positive regulation of transcription, DNA-templated
GO:45995; regulation of embryonic development
GO:46223; aflatoxin catabolic process
GO:46326; positive regulation of glucose import
GO:60548; negative regulation of cell death
GO:71280; cellular response to copper ion
GO:71456; cellular response to hypoxia
GO:71466; cellular response to xenobiotic stimulus
GO:1902037; negative regulation of hematopoietic stem cell differentiation
GO:1903788; positive regulation of glutathione biosynthetic process
GO:1904385; cellular response to angiotensin
GO:1904753; negative regulation of vascular associated smooth muscle cell migration
GO:2000121; regulation of removal of superoxide radicals
GO:2000379; positive regulation of reactive oxygen species metabolic process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5813; centrosome
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:32993; protein-DNA complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:19904; protein domain specific binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:1221; transcription coregulator binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
Hide GO terms

Homologs of NFE2L2 in Model Organisms

Danio rerio
nfe2l2a
Mus musculus
Nfe2l2
Rattus norvegicus
Nfe2l2

In other databases

GenAge human genes
  • This gene is present as NFE2L2

External links

OMIM
600492
Ensembl
ENSG00000116044
Entrez Gene
4780
UniGene
744006
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NFE2L2
GeneCards
NFE2L2