Cell Senescence Entries for NFKBIA

Cell Types
Cervical cancer, Glioblastoma
Cell Lines
HeLa, U87
Cancer Cell?
Yes
Method
Mutation, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Zhi et al. (2011) NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ. PLoS Pathog 7(4)e1002025 (PubMed)

NFKBIA Gene Information

HGNC symbol
NFKBIA 
Aliases
IkappaBalpha; IKBA; MAD-3; NFKBI 
Common name
NFKB inhibitor alpha 
Entrez Id
4792
Description
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011].

NFKBIA Ontologies

Gene Ontology
Process: GO:45944; positive regulation of transcription by RNA polymerase II
GO:42994; cytoplasmic sequestering of transcription factor
GO:6915; apoptotic process
GO:7249; I-kappaB kinase/NF-kappaB signaling
GO:32270; positive regulation of cellular protein metabolic process
GO:10745; negative regulation of macrophage derived foam cell differentiation
GO:10888; negative regulation of lipid storage
GO:10875; positive regulation of cholesterol efflux
GO:43392; negative regulation of DNA binding
GO:1901222; regulation of NIK/NF-kappaB signaling
GO:32088; negative regulation of NF-kappaB transcription factor activity
GO:6606; protein import into nucleus
GO:7253; cytoplasmic sequestering of NF-kappaB
GO:10468; regulation of gene expression
GO:31663; lipopolysaccharide-mediated signaling pathway
GO:32495; response to muramyl dipeptide
GO:32496; response to lipopolysaccharide
GO:33209; tumor necrosis factor-mediated signaling pathway
GO:34142; toll-like receptor 4 signaling pathway
GO:35994; response to muscle stretch
GO:42127; regulation of cell population proliferation
GO:43330; response to exogenous dsRNA
GO:45638; negative regulation of myeloid cell differentiation
GO:45746; negative regulation of Notch signaling pathway
GO:45893; positive regulation of transcription, DNA-templated
GO:50729; positive regulation of inflammatory response
GO:70417; cellular response to cold
GO:70427; nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:70431; nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:71356; cellular response to tumor necrosis factor
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5654; nucleoplasm
GO:33256; I-kappaB/NF-kappaB complex
Function: GO:5515; protein binding
GO:31625; ubiquitin protein ligase binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:51059; NF-kappaB binding
GO:8134; transcription factor binding
GO:8139; nuclear localization sequence binding
Hide GO terms

Homologs of NFKBIA in Model Organisms

Danio rerio
nfkbiaa
Drosophila melanogaster
cact
Mus musculus
Nfkbia
Rattus norvegicus
Nfkbia

In other databases

GenAge human genes
  • This gene is present as NFKBIA
GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Nfkbia

External links

OMIM
164008
Ensembl
ENSG00000100906
Entrez Gene
4792
UniGene
81328
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NFKBIA
GeneCards
NFKBIA