Cell Senescence Entries for NINJ1

Cell Types
Liver cancer
Cell Lines
Huh7
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Toyama et al. (2005) Ninjurin1 increases p21 expression and induces cellular senescence in human hepatoma cells. J Hepatol 41(4)637-43 (PubMed)

NINJ1 Gene Information

HGNC symbol
NINJ1 
Aliases
NIN1 
Common name
ninjurin 1 
Entrez Id
4814
Description
The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009].

NINJ1 Ontologies

Gene Ontology
Process: GO:7155; cell adhesion
GO:12501; programmed cell death
GO:6954; inflammatory response
GO:1525; angiogenesis
GO:19835; cytolysis
GO:42246; tissue regeneration
GO:51260; protein homooligomerization
GO:50729; positive regulation of inflammatory response
GO:7399; nervous system development
GO:45766; positive regulation of angiogenesis
GO:2232; leukocyte chemotaxis involved in inflammatory response
GO:70265; necrotic cell death
GO:34145; positive regulation of toll-like receptor 4 signaling pathway
GO:34113; heterotypic cell-cell adhesion
GO:42692; muscle cell differentiation
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5576; extracellular region
GO:30054; cell junction
GO:45202; synapse
GO:97060; synaptic membrane
Function: GO:5515; protein binding
GO:1530; lipopolysaccharide binding
GO:98631; cell adhesion mediator activity
Hide GO terms

Homologs of NINJ1 in Model Organisms

Danio rerio
LOC100150223
Drosophila melanogaster
NijC
Mus musculus
Ninj1
Rattus norvegicus
Ninj1

External links

OMIM
602062
Ensembl
ENSG00000131669
Entrez Gene
4814
UniGene
494457
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NINJ1
GeneCards
NINJ1