Cell Senescence Entries for NOTCH1

Cell Types
Esophageal keratinocyte
Cell Lines
EPC1, EPC1-hTERT, EPC2-hTERT
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Kagawa et al. (2015) Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities. Oncogene 34(18)2347-59 (PubMed)

NOTCH1 Gene Information

HGNC symbol
NOTCH1 
Aliases
TAN1 
Common name
notch receptor 1 
Entrez Id
4851
Description
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016].

NOTCH1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:7219; Notch signaling pathway
GO:1525; angiogenesis
GO:50793; regulation of developmental process
GO:7275; multicellular organism development
GO:10628; positive regulation of gene expression
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:6955; immune response
GO:60271; cilium assembly
GO:10629; negative regulation of gene expression
GO:8284; positive regulation of cell population proliferation
GO:8285; negative regulation of cell population proliferation
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:30513; positive regulation of BMP signaling pathway
GO:30335; positive regulation of cell migration
GO:120163; negative regulation of cold-induced thermogenesis
GO:45892; negative regulation of transcription, DNA-templated
GO:1947; heart looping
GO:7368; determination of left/right symmetry
GO:45662; negative regulation of myoblast differentiation
GO:97150; neuronal stem cell population maintenance
GO:3151; outflow tract morphogenesis
GO:35148; tube formation
GO:35924; cellular response to vascular endothelial growth factor stimulus
GO:90051; negative regulation of cell migration involved in sprouting angiogenesis
GO:43086; negative regulation of catalytic activity
GO:7411; axon guidance
GO:30514; negative regulation of BMP signaling pathway
GO:60412; ventricular septum morphogenesis
GO:60317; cardiac epithelial to mesenchymal transition
GO:3181; atrioventricular valve morphogenesis
GO:3203; endocardial cushion morphogenesis
GO:55008; cardiac muscle tissue morphogenesis
GO:46579; positive regulation of Ras protein signal transduction
GO:3180; aortic valve morphogenesis
GO:3184; pulmonary valve morphogenesis
GO:30279; negative regulation of ossification
GO:45668; negative regulation of osteoblast differentiation
GO:1837; epithelial to mesenchymal transition
GO:3198; epithelial to mesenchymal transition involved in endocardial cushion formation
GO:3273; cell migration involved in endocardial cushion formation
GO:61314; Notch signaling involved in heart development
GO:2000811; negative regulation of anoikis
GO:3213; cardiac right atrium morphogenesis
GO:10812; negative regulation of cell-substrate adhesion
GO:70168; negative regulation of biomineral tissue development
GO:10614; negative regulation of cardiac muscle hypertrophy
GO:60045; positive regulation of cardiac muscle cell proliferation
GO:2000737; negative regulation of stem cell differentiation
GO:60411; cardiac septum morphogenesis
GO:1901201; regulation of extracellular matrix assembly
GO:2001027; negative regulation of endothelial cell chemotaxis
GO:10832; negative regulation of myotube differentiation
GO:60354; negative regulation of cell adhesion molecule production
GO:46427; positive regulation of receptor signaling pathway via JAK-STAT
GO:48711; positive regulation of astrocyte differentiation
GO:3169; coronary vein morphogenesis
GO:60948; cardiac vascular smooth muscle cell development
GO:60982; coronary artery morphogenesis
GO:2000048; negative regulation of cell-cell adhesion mediated by cadherin
GO:3214; cardiac left ventricle morphogenesis
GO:3208; cardiac ventricle morphogenesis
GO:3209; cardiac atrium morphogenesis
GO:3222; ventricular trabecula myocardium morphogenesis
GO:3344; pericardium morphogenesis
GO:61384; heart trabecula morphogenesis
GO:3332; negative regulation of extracellular matrix constituent secretion
GO:1902339; positive regulation of apoptotic process involved in morphogenesis
GO:50768; negative regulation of neurogenesis
GO:48873; homeostasis of number of cells within a tissue
GO:60956; endocardial cell differentiation
GO:60253; negative regulation of glial cell proliferation
GO:1701; in utero embryonic development
GO:1708; cell fate specification
GO:1889; liver development
GO:2040; sprouting angiogenesis
GO:2052; positive regulation of neuroblast proliferation
GO:2437; inflammatory response to antigenic stimulus
GO:3157; endocardium development
GO:3160; endocardium morphogenesis
GO:3162; atrioventricular node development
GO:3182; coronary sinus valve morphogenesis
GO:3192; mitral valve formation
GO:3197; endocardial cushion development
GO:3207; cardiac chamber formation
GO:3219; cardiac right ventricle formation
GO:3241; growth involved in heart morphogenesis
GO:3252; negative regulation of cell proliferation involved in heart valve morphogenesis
GO:3256; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:3264; regulation of cardioblast proliferation
GO:3270; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO:6357; regulation of transcription by RNA polymerase II
GO:6606; protein import into nucleus
GO:6959; humoral immune response
GO:7221; positive regulation of transcription of Notch receptor target
GO:7283; spermatogenesis
GO:7386; compartment pattern specification
GO:7409; axonogenesis
GO:7420; brain development
GO:7440; foregut morphogenesis
GO:7492; endoderm development
GO:7507; heart development
GO:8544; epidermis development
GO:8593; regulation of Notch signaling pathway
GO:9912; auditory receptor cell fate commitment
GO:10001; glial cell differentiation
GO:10467; gene expression
GO:10468; regulation of gene expression
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:14031; mesenchymal cell development
GO:14807; regulation of somitogenesis
GO:21515; cell differentiation in spinal cord
GO:21915; neural tube development
GO:30163; protein catabolic process
GO:30182; neuron differentiation
GO:30216; keratinocyte differentiation
GO:30324; lung development
GO:30326; embryonic limb morphogenesis
GO:30334; regulation of cell migration
GO:30900; forebrain development
GO:31069; hair follicle morphogenesis
GO:31100; animal organ regeneration
GO:31960; response to corticosteroid
GO:32495; response to muramyl dipeptide
GO:32496; response to lipopolysaccharide
GO:35116; embryonic hindlimb morphogenesis
GO:35914; skeletal muscle cell differentiation
GO:42127; regulation of cell population proliferation
GO:42246; tissue regeneration
GO:43065; positive regulation of apoptotic process
GO:45070; positive regulation of viral genome replication
GO:45165; cell fate commitment
GO:45596; negative regulation of cell differentiation
GO:45603; positive regulation of endothelial cell differentiation
GO:45607; regulation of inner ear auditory receptor cell differentiation
GO:45608; negative regulation of inner ear auditory receptor cell differentiation
GO:45618; positive regulation of keratinocyte differentiation
GO:45665; negative regulation of neuron differentiation
GO:45687; positive regulation of glial cell differentiation
GO:45747; positive regulation of Notch signaling pathway
GO:45955; negative regulation of calcium ion-dependent exocytosis
GO:46533; negative regulation of photoreceptor cell differentiation
GO:48103; somatic stem cell division
GO:48663; neuron fate commitment
GO:48708; astrocyte differentiation
GO:48709; oligodendrocyte differentiation
GO:48715; negative regulation of oligodendrocyte differentiation
GO:48754; branching morphogenesis of an epithelial tube
GO:48845; venous blood vessel morphogenesis
GO:50678; regulation of epithelial cell proliferation
GO:50679; positive regulation of epithelial cell proliferation
GO:50767; regulation of neurogenesis
GO:60038; cardiac muscle cell proliferation
GO:60528; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:60548; negative regulation of cell death
GO:60740; prostate gland epithelium morphogenesis
GO:60768; regulation of epithelial cell proliferation involved in prostate gland development
GO:60842; arterial endothelial cell differentiation
GO:60843; venous endothelial cell differentiation
GO:60979; vasculogenesis involved in coronary vascular morphogenesis
GO:61419; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:62043; positive regulation of cardiac epithelial to mesenchymal transition
GO:70986; left/right axis specification
GO:71228; cellular response to tumor cell
GO:71372; cellular response to follicle-stimulating hormone stimulus
GO:72017; distal tubule development
GO:72044; collecting duct development
GO:72144; glomerular mesangial cell development
GO:72538; T-helper 17 type immune response
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:97400; interleukin-17-mediated signaling pathway
GO:1902263; apoptotic process involved in embryonic digit morphogenesis
GO:1903849; positive regulation of aorta morphogenesis
GO:2000974; negative regulation of pro-B cell differentiation
Cellular component: GO:5634; nucleus
GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5912; adherens junction
GO:16324; apical plasma membrane
GO:5576; extracellular region
GO:5789; endoplasmic reticulum membrane
GO:5654; nucleoplasm
GO:5829; cytosol
GO:9986; cell surface
GO:139; Golgi membrane
GO:43235; receptor complex
GO:1669; acrosomal vesicle
GO:2193; MAML1-RBP-Jkappa- ICN1 complex
GO:5737; cytoplasm
GO:5783; endoplasmic reticulum
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:71944; cell periphery
Function: GO:5509; calcium ion binding
GO:38023; signaling receptor activity
GO:5515; protein binding
GO:46872; metal ion binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:4857; enzyme inhibitor activity
GO:3713; transcription coactivator activity
GO:3682; chromatin binding
GO:4888; transmembrane signaling receptor activity
GO:5112; Notch binding
GO:31490; chromatin DNA binding
Hide GO terms

Homologs of NOTCH1 in Model Organisms

Danio rerio
notch1a
Mus musculus
Notch1
Rattus norvegicus
Notch1

External links

OMIM
190198
Ensembl
ENSG00000148400
Entrez Gene
4851
UniGene
495473
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NOTCH1
GeneCards
NOTCH1