Cell Senescence Entries for NOTCH3

Cell Types
Breast cancer, Fibroblast, Foreskin fibroblast, Glioblastoma, Melanoma
Cell Lines
A375P, BJ, LF1, MDA-MB-231, T98G, WS1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Cui et al. (2014) Notch3 functions as a tumor suppressor by controlling cellular senescence. Cancer Res 73(11)3451-9 (PubMed)

NOTCH3 Gene Information

HGNC symbol
NOTCH3 
Aliases
CADASIL; CASIL 
Common name
notch receptor 3 
Entrez Id
4854
Description
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008].

NOTCH3 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:7219; Notch signaling pathway
GO:50793; regulation of developmental process
GO:7411; axon guidance
GO:122; negative regulation of transcription by RNA polymerase II
GO:30900; forebrain development
GO:45596; negative regulation of cell differentiation
GO:45665; negative regulation of neuron differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:48661; positive regulation of smooth muscle cell proliferation
GO:48663; neuron fate commitment
GO:48844; artery morphogenesis
GO:72104; glomerular capillary formation
GO:7275; multicellular organism development
Cellular component: GO:5634; nucleus
GO:16020; membrane
GO:16021; integral component of membrane
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:15629; actin cytoskeleton
GO:5576; extracellular region
GO:5789; endoplasmic reticulum membrane
GO:9986; cell surface
GO:139; Golgi membrane
GO:43235; receptor complex
Function: GO:5509; calcium ion binding
GO:5515; protein binding
GO:38023; signaling receptor activity
GO:42802; identical protein binding
GO:45296; cadherin binding
GO:19899; enzyme binding
Hide GO terms

Homologs of NOTCH3 in Model Organisms

Mus musculus
Notch3
Rattus norvegicus
Notch3

External links

OMIM
600276
Ensembl
ENSG00000074181
Entrez Gene
4854
UniGene
8546
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NOTCH3
GeneCards
NOTCH3