Cell Senescence Entries for NOX1

Cell Types
Pulmonary artery endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Meijles et al. (2018) The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1. Sci Signal 10(501)117-26 (PubMed)

NOX1 Gene Information

HGNC symbol
NOX1 
Aliases
GP91-2; MOX1; NOH-1; NOH1 
Common name
NADPH oxidase 1 
Entrez Id
27035
Description
This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012].

NOX1 Ontologies

Gene Ontology
Process: GO:6811; ion transport
GO:34220; ion transmembrane transport
GO:34765; regulation of ion transmembrane transport
GO:6952; defense response
GO:42554; superoxide anion generation
GO:8284; positive regulation of cell population proliferation
GO:6954; inflammatory response
GO:1525; angiogenesis
GO:16477; cell migration
GO:7165; signal transduction
GO:8217; regulation of blood pressure
GO:10575; positive regulation of vascular endothelial growth factor production
GO:48661; positive regulation of smooth muscle cell proliferation
GO:45730; respiratory burst
GO:45726; positive regulation of integrin biosynthetic process
GO:6739; NADP metabolic process
GO:3081; regulation of systemic arterial blood pressure by renin-angiotensin
GO:30198; extracellular matrix organization
GO:42743; hydrogen peroxide metabolic process
GO:43410; positive regulation of MAPK cascade
GO:46330; positive regulation of JNK cascade
GO:51454; intracellular pH elevation
GO:71455; cellular response to hyperoxia
GO:72592; oxygen metabolic process
GO:1902177; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1990451; cellular stress response to acidic pH
GO:72593; reactive oxygen species metabolic process
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:30054; cell junction
GO:42995; cell projection
GO:5769; early endosome
GO:43020; NADPH oxidase complex
GO:5737; cytoplasm
GO:5768; endosome
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:5244; voltage-gated ion channel activity
GO:16175; superoxide-generating NAD(P)H oxidase activity
GO:31267; small GTPase binding
GO:50661; NADP binding
Hide GO terms

Homologs of NOX1 in Model Organisms

Mus musculus
Nox1
Rattus norvegicus
Nox1

In other databases

LongevityMap
  • This gene is present as NOX1

External links

OMIM
300225
Ensembl
ENSG00000007952
Entrez Gene
27035
UniGene
592227
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NOX1
GeneCards
NOX1