Cell Senescence Entries for NOX4

Cell Types
Breast epithelial, Lung fibroblast
Cell Lines
MCF-12A, TIG-3
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Graham et al. (2011) NADPH oxidase 4 is an oncoprotein localized to mitochondria. Cancer Biol Ther 10(3)223-31 (PubMed)
Cell Types
Breast epithelial, Lung fibroblast
Cell Lines
MCF-12A, TIG-3
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Kodama et al. (2013) ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence. Genes Cells 18(1)32-41 (PubMed)

NOX4 Gene Information

HGNC symbol
NOX4 
Aliases
KOX; KOX-1 
Common name
NADPH oxidase 4 
Entrez Id
50507
Description
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009].

NOX4 Ontologies

Gene Ontology
Process: GO:6954; inflammatory response
GO:22900; electron transport chain
GO:72593; reactive oxygen species metabolic process
GO:8285; negative regulation of cell population proliferation
GO:6952; defense response
GO:42554; superoxide anion generation
GO:7569; cell aging
GO:61098; positive regulation of protein tyrosine kinase activity
GO:3015; heart process
GO:902; cell morphogenesis
GO:50667; homocysteine metabolic process
GO:6801; superoxide metabolic process
GO:10467; gene expression
GO:1903409; reactive oxygen species biosynthetic process
GO:43406; positive regulation of MAP kinase activity
GO:45453; bone resorption
GO:51897; positive regulation of protein kinase B signaling
GO:55007; cardiac muscle cell differentiation
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:71333; cellular response to glucose stimulus
GO:2000573; positive regulation of DNA biosynthetic process
Cellular component: GO:5634; nucleus
GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5886; plasma membrane
GO:5925; focal adhesion
GO:30054; cell junction
GO:5730; nucleolus
GO:48471; perinuclear region of cytoplasm
GO:5739; mitochondrion
GO:43020; NADPH oxidase complex
GO:97038; perinuclear endoplasmic reticulum
GO:71944; cell periphery
Function: GO:166; nucleotide binding
GO:16174; NAD(P)H oxidase H2O2-forming activity
GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:50660; flavin adenine dinucleotide binding
GO:20037; heme binding
GO:9055; electron transfer activity
GO:19826; oxygen sensor activity
GO:1990782; protein tyrosine kinase binding
GO:72341; modified amino acid binding
GO:16175; superoxide-generating NAD(P)H oxidase activity
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Homologs of NOX4 in Model Organisms

Mus musculus
Nox4
Rattus norvegicus
Nox4

External links

OMIM
605261
Ensembl
ENSG00000086991
Entrez Gene
50507
UniGene
371036
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NOX4
GeneCards
NOX4