Cell Senescence Entries for NPM1

Cell Types
Colon cancer
Cell Lines
MIP-101
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Wong et al. (2013) Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53-mediated cellular senescence. Int J Cancer 133(7)1567-77 (PubMed)

NPM1 Gene Information

HGNC symbol
NPM1 
Aliases
B23; NPM 
Common name
nucleophosmin 1 
Entrez Id
4869
Description
The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017].

NPM1 Ontologies

Gene Ontology
Process: GO:6886; intracellular protein transport
GO:43066; negative regulation of apoptotic process
GO:6334; nucleosome assembly
GO:7165; signal transduction
GO:6281; DNA repair
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:6913; nucleocytoplasmic transport
GO:8284; positive regulation of cell population proliferation
GO:8285; negative regulation of cell population proliferation
GO:6338; chromatin remodeling
GO:7098; centrosome cycle
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:8104; protein localization
GO:45727; positive regulation of translation
GO:55; ribosomal large subunit export from nucleus
GO:56; ribosomal small subunit export from nucleus
GO:7569; cell aging
GO:1902751; positive regulation of cell cycle G2/M phase transition
GO:42273; ribosomal large subunit biogenesis
GO:42274; ribosomal small subunit biogenesis
GO:34644; cellular response to UV
GO:6407; rRNA export from nucleus
GO:10824; regulation of centrosome duplication
GO:10826; negative regulation of centrosome duplication
GO:32071; regulation of endodeoxyribonuclease activity
GO:42255; ribosome assembly
GO:44387; negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:46599; regulation of centriole replication
GO:60699; regulation of endoribonuclease activity
GO:60735; regulation of eIF2 alpha phosphorylation by dsRNA
GO:1902629; regulation of mRNA stability involved in cellular response to UV
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:5815; microtubule organizing center
GO:5813; centrosome
GO:5829; cytosol
GO:1990904; ribonucleoprotein complex
GO:32991; protein-containing complex
GO:32993; protein-DNA complex
GO:31616; spindle pole centrosome
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:51082; unfolded protein binding
GO:4860; protein kinase inhibitor activity
GO:3713; transcription coactivator activity
GO:3682; chromatin binding
GO:42393; histone binding
GO:19901; protein kinase binding
GO:30957; Tat protein binding
GO:51059; NF-kappaB binding
GO:140297; DNA-binding transcription factor binding
GO:1046; core promoter sequence-specific DNA binding
GO:43023; ribosomal large subunit binding
GO:43024; ribosomal small subunit binding
Hide GO terms

Homologs of NPM1 in Model Organisms

Danio rerio
npm1a
Mus musculus
Npm1
Rattus norvegicus
Npm1

In other databases

CellAge gene expression
  • This gene is present as NPM1

External links

OMIM
164040
Ensembl
ENSG00000181163
Entrez Gene
4869
UniGene
557550
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NPM1
GeneCards
NPM1