Cell Senescence Entries for NR1H2

Cell Types
Umbilical vein endothelial
Cell Lines
HUVEC
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Hayashi et al. (2014) Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes. Proc Natl Acad Sci U S A 111(3)1168-73 (PubMed)

NR1H2 Gene Information

HGNC symbol
NR1H2 
Aliases
LXR-b; LXRb; NER; NER-I; RIP15; UNR 
Common name
nuclear receptor subfamily 1 group H member 2 
Entrez Id
7376
Description
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010].

NR1H2 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6629; lipid metabolic process
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:36151; phosphatidylcholine acyl-chain remodeling
GO:122; negative regulation of transcription by RNA polymerase II
GO:30154; cell differentiation
GO:120163; negative regulation of cold-induced thermogenesis
GO:42789; mRNA transcription by RNA polymerase II
GO:42632; cholesterol homeostasis
GO:32270; positive regulation of cellular protein metabolic process
GO:1903573; negative regulation of response to endoplasmic reticulum stress
GO:45892; negative regulation of transcription, DNA-templated
GO:10745; negative regulation of macrophage derived foam cell differentiation
GO:10887; negative regulation of cholesterol storage
GO:10867; positive regulation of triglyceride biosynthetic process
GO:10875; positive regulation of cholesterol efflux
GO:45723; positive regulation of fatty acid biosynthetic process
GO:51006; positive regulation of lipoprotein lipase activity
GO:32369; negative regulation of lipid transport
GO:32376; positive regulation of cholesterol transport
GO:9755; hormone-mediated signaling pathway
GO:60336; negative regulation of interferon-gamma-mediated signaling pathway
GO:48550; negative regulation of pinocytosis
GO:6357; regulation of transcription by RNA polymerase II
GO:10628; positive regulation of gene expression
GO:10629; negative regulation of gene expression
GO:10884; positive regulation of lipid storage
GO:31667; response to nutrient levels
GO:44255; cellular lipid metabolic process
GO:45861; negative regulation of proteolysis
GO:48384; retinoic acid receptor signaling pathway
GO:55088; lipid homeostasis
GO:90108; positive regulation of high-density lipoprotein particle assembly
GO:90187; positive regulation of pancreatic juice secretion
GO:90340; positive regulation of secretion of lysosomal enzymes
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:7165; signal transduction
GO:30522; intracellular receptor signaling pathway
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
GO:5829; cytosol
GO:5737; cytoplasm
GO:90575; RNA polymerase II transcription regulator complex
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:4879; nuclear receptor activity
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:51117; ATPase binding
GO:34191; apolipoprotein A-I receptor binding
GO:46965; retinoid X receptor binding
Hide GO terms

Homologs of NR1H2 in Model Organisms

Mus musculus
Nr1h2
Rattus norvegicus
Nr1h2

External links

OMIM
600380
Ensembl
ENSG00000131408
Entrez Gene
7376
UniGene
432976
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NR1H2
GeneCards
NR1H2