Cell Senescence Entries for NR2E1

Cell Types
Lung fibroblast, Neural stem, Prostate epithelial
Cell Lines
IMR-90, WI-38
Cancer Cell?
No
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Unclear
Primary Reference
O'Loghlen et al. (2015) The nuclear receptor NR2E1/TLX controls senescence. Oncogene 34(31)4069-4077 (PubMed)

NR2E1 Gene Information

HGNC symbol
NR2E1 
Aliases
TLL; TLX; XTLL 
Common name
nuclear receptor subfamily 2 group E member 1 
Entrez Id
7101
Description
The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015].

NR2E1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:30522; intracellular receptor signaling pathway
GO:43401; steroid hormone mediated signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:30154; cell differentiation
GO:1662; behavioral fear response
GO:2118; aggressive behavior
GO:7420; brain development
GO:7601; visual perception
GO:8284; positive regulation of cell population proliferation
GO:8347; glial cell migration
GO:21542; dentate gyrus development
GO:21764; amygdala development
GO:21772; olfactory bulb development
GO:21819; layer formation in cerebral cortex
GO:21872; forebrain generation of neurons
GO:21895; cerebral cortex neuron differentiation
GO:21960; anterior commissure morphogenesis
GO:21987; cerebral cortex development
GO:30198; extracellular matrix organization
GO:35019; somatic stem cell population maintenance
GO:35176; social behavior
GO:43010; camera-type eye development
GO:43066; negative regulation of apoptotic process
GO:45165; cell fate commitment
GO:45665; negative regulation of neuron differentiation
GO:45766; positive regulation of angiogenesis
GO:45787; positive regulation of cell cycle
GO:48712; negative regulation of astrocyte differentiation
GO:48814; regulation of dendrite morphogenesis
GO:51128; regulation of cellular component organization
GO:60041; retina development in camera-type eye
GO:60164; regulation of timing of neuron differentiation
GO:60291; long-term synaptic potentiation
GO:90049; regulation of cell migration involved in sprouting angiogenesis
GO:2000178; negative regulation of neural precursor cell proliferation
GO:2000179; positive regulation of neural precursor cell proliferation
GO:2000648; positive regulation of stem cell proliferation
GO:7399; nervous system development
GO:48856; anatomical structure development
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:4879; nuclear receptor activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1990837; sequence-specific double-stranded DNA binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:19899; enzyme binding
GO:42826; histone deacetylase binding
GO:3707; steroid hormone receptor activity
Hide GO terms

Homologs of NR2E1 in Model Organisms

Danio rerio
nr2e1
Drosophila melanogaster
dsf
Mus musculus
Nr2e1
Rattus norvegicus
Nr2e1

External links

OMIM
603849
Ensembl
ENSG00000112333
Entrez Gene
7101
UniGene
157688
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NR2E1
GeneCards
NR2E1