Cell Senescence Entries for NTN4

Cell Types
Glioblastoma, Glioma
Cell Lines
T98G, U-251MG, U-87MG, U-U118MG
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Li et al. (2014) NETRIN-4 protects glioblastoma cells FROM temozolomide induced senescence. PLoS One 8(11)e80363 (PubMed)

NTN4 Gene Information

HGNC symbol
NTN4 
Aliases
 
Common name
netrin 4 
Entrez Id
59277
Description
This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016].

NTN4 Ontologies

Gene Ontology
Process: GO:16477; cell migration
GO:9887; animal organ morphogenesis
GO:9888; tissue development
GO:34446; substrate adhesion-dependent cell spreading
GO:70831; basement membrane assembly
GO:16322; neuron remodeling
GO:60668; regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling
Cellular component: GO:5576; extracellular region
GO:5604; basement membrane
GO:5886; plasma membrane
GO:43256; laminin complex
Function: GO:5515; protein binding
GO:43237; laminin-1 binding
Hide GO terms

Homologs of NTN4 in Model Organisms

Danio rerio
BX005001.1
Mus musculus
Ntn4
Rattus norvegicus
Ntn4

In other databases

CellAge gene expression
  • This gene is present as NTN4

External links

OMIM
610401
Ensembl
ENSG00000074527
Entrez Gene
59277
UniGene
201034
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NTN4
GeneCards
NTN4