Cell Senescence Entries for NUDT5
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Zhang et al. (2014) Lowered Nudix type 5 expression leads to cellular senescence in IMR-90 fibroblast cells. Free Radic Res 47(6-7)511-6 (PubMed)
NUDT5 Gene Information
- HGNC symbol
- NUDT5
- Aliases
- hYSAH1; YSA1H
- Common name
- nudix hydrolase 5
- Entrez Id
- 11164
- Description
- This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013].
NUDT5 Ontologies
- Gene Ontology
-
Process: GO:6338; chromatin remodeling
GO:6753; nucleoside phosphate metabolic process
GO:19693; ribose phosphate metabolic process
GO:1990966; ATP generation from poly-ADP-D-ribose
GO:55086; nucleobase-containing small molecule metabolic process
GO:19303; D-ribose catabolic process
GO:6139; nucleobase-containing compound metabolic process
GO:9117; nucleotide metabolic process
GO:9191; ribonucleoside diphosphate catabolic process
Cellular component: GO:5634; nucleus
GO:5829; cytosol
GO:70062; extracellular exosome
Hide GO termsFunction: GO:3723; RNA binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:16787; hydrolase activity
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:16779; nucleotidyltransferase activity
GO:287; magnesium ion binding
GO:42802; identical protein binding
GO:30515; snoRNA binding
GO:47631; ADP-ribose diphosphatase activity
GO:44715; 8-oxo-dGDP phosphatase activity
GO:44716; 8-oxo-GDP phosphatase activity
GO:19144; ADP-sugar diphosphatase activity
GO:17110; nucleoside-diphosphatase activity
Homologs of NUDT5 in Model Organisms
- Caenorhabditis elegans
- ndx-2
- Danio rerio
- nudt5
- Mus musculus
- Nudt5
- Rattus norvegicus
- Nudt5
- Saccharomyces cerevisiae
- YSA1
- Schizosaccharomyces pombe
- SPBP35G2.12
External links
- OMIM
- 609230
- Ensembl
- ENSG00000165609
- Entrez Gene
- 11164
- UniGene
- 656304
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- NUDT5
- GeneCards
- NUDT5