Cell Senescence Entries for NUTF2
- Cell Types
- Skin fibroblast
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Larrieu et al. (2019) Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway. Sci Signal 11(537)117-26 (PubMed)
NUTF2 Gene Information
- HGNC symbol
- NUTF2
- Aliases
- NTF2; PP15
- Common name
- nuclear transport factor 2
- Entrez Id
- 10204
- Description
- This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016].
NUTF2 Ontologies
- Gene Ontology
-
Process: GO:51028; mRNA transport
GO:15031; protein transport
GO:6913; nucleocytoplasmic transport
GO:6606; protein import into nucleus
GO:6611; protein export from nucleus
GO:90204; protein localization to nuclear pore
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5643; nuclear pore
GO:31965; nuclear membrane
GO:5654; nucleoplasm
GO:5637; nuclear inner membrane
GO:5640; nuclear outer membrane
GO:70062; extracellular exosome
GO:44613; nuclear pore central transport channel
Hide GO termsFunction: GO:5515; protein binding
GO:42802; identical protein binding
GO:17056; structural constituent of nuclear pore
GO:31267; small GTPase binding
Homologs of NUTF2 in Model Organisms
- Caenorhabditis elegans
- ran-4
- Danio rerio
- nutf2
- Drosophila melanogaster
- Ntf-2
- Mus musculus
- Nutf2
- Rattus norvegicus
- Nutf2
- Saccharomyces cerevisiae
- NTF2
- Schizosaccharomyces pombe
- ntf2
External links
- OMIM
- 605813
- Ensembl
- ENSG00000102898
- Entrez Gene
- 10204
- UniGene
- 356630
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- NUTF2
- GeneCards
- NUTF2