Cell Senescence Entries for OGG1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Ramdzan et al. (2014) RAS transformation requires CUX1-dependent repair of oxidative DNA damage. PLoS Biol 12(3)e1001807 (PubMed)

OGG1 Gene Information

HGNC symbol
OGG1 
Aliases
HMMH; HOGG1; MUTM; OGH1 
Common name
8-oxoguanine DNA glycosylase 
Entrez Id
4968
Description
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008].

OGG1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:8152; metabolic process
GO:6284; base-excision repair
GO:6289; nucleotide-excision repair
GO:6979; response to oxidative stress
GO:33683; nucleotide-excision repair, DNA incision
GO:1901291; negative regulation of double-strand break repair via single-strand annealing
GO:6285; base-excision repair, AP site formation
GO:9314; response to radiation
GO:45007; depurination
GO:45008; depyrimidination
GO:2526; acute inflammatory response
GO:7568; aging
GO:9410; response to xenobiotic stimulus
GO:9416; response to light stimulus
GO:32355; response to estradiol
GO:43066; negative regulation of apoptotic process
GO:45471; response to ethanol
GO:51593; response to folic acid
GO:71276; cellular response to cadmium ion
Cellular component: GO:5634; nucleus
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:16363; nuclear matrix
GO:5829; cytosol
GO:5759; mitochondrial matrix
GO:32991; protein-containing complex
Function: GO:16787; hydrolase activity
GO:3824; catalytic activity
GO:16829; lyase activity
GO:3684; damaged DNA binding
GO:16798; hydrolase activity, acting on glycosyl bonds
GO:140078; class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:5515; protein binding
GO:8534; oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:34039; 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:4519; endonuclease activity
GO:32357; oxidized purine DNA binding
GO:3677; DNA binding
GO:8017; microtubule binding
GO:19104; DNA N-glycosylase activity
Hide GO terms

Homologs of OGG1 in Model Organisms

Danio rerio
ogg1
Drosophila melanogaster
Ogg1
Mus musculus
Ogg1
Rattus norvegicus
Ogg1
Saccharomyces cerevisiae
OGG1

In other databases

LongevityMap
  • This gene is present as OGG1

External links

OMIM
601982
Ensembl
ENSG00000114026
Entrez Gene
4968
UniGene
380271
1000 Genomes
1000 Genomes
HPRD
GenAtlas
OGG1
GeneCards
OGG1