Cell Senescence Entries for OGT

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Lee et al. (2017) O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence. Proc Natl Acad Sci U S A 113(23)E3213-20 (PubMed)

OGT Gene Information

HGNC symbol
OGT 
Aliases
FLJ23071; HRNT1; MGC22921; O-GLCNAC; OGT1 
Common name
O-linked N-acetylglucosamine (GlcNAc) transferase 
Entrez Id
8473
Description
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009].

OGT Ontologies

Gene Ontology
Process: GO:6915; apoptotic process
GO:6325; chromatin organization
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6486; protein glycosylation
GO:48511; rhythmic process
GO:32922; circadian regulation of gene expression
GO:48015; phosphatidylinositol-mediated signaling
GO:6493; protein O-linked glycosylation
GO:6357; regulation of transcription by RNA polymerase II
GO:43981; histone H4-K5 acetylation
GO:43982; histone H4-K8 acetylation
GO:16485; protein processing
GO:32435; negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:7165; signal transduction
GO:122; negative regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:120162; positive regulation of cold-induced thermogenesis
GO:31397; negative regulation of protein ubiquitination
GO:46626; regulation of insulin receptor signaling pathway
GO:32868; response to insulin
GO:423; mitophagy
GO:6110; regulation of glycolytic process
GO:6111; regulation of gluconeogenesis
GO:7584; response to nutrient
GO:30097; hemopoiesis
GO:35020; regulation of Rac protein signal transduction
GO:43984; histone H4-K16 acetylation
GO:45862; positive regulation of proteolysis
GO:51571; positive regulation of histone H3-K4 methylation
GO:60544; regulation of necroptotic process
GO:61087; positive regulation of histone H3-K27 methylation
GO:80182; histone H3-K4 trimethylation
GO:1900095; regulation of dosage compensation by inactivation of X chromosome
GO:30336; negative regulation of cell migration
GO:1902459; positive regulation of stem cell population maintenance
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:1902455; negative regulation of stem cell population maintenance
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:42995; cell projection
GO:123; histone acetyltransferase complex
GO:31966; mitochondrial membrane
GO:44545; NSL complex
GO:17122; protein N-acetylglucosaminyltransferase complex
GO:16580; Sin3 complex
Function: GO:16740; transferase activity
GO:16757; glycosyltransferase activity
GO:5515; protein binding
GO:8289; lipid binding
GO:5547; phosphatidylinositol-3,4,5-trisphosphate binding
GO:8375; acetylglucosaminyltransferase activity
GO:16262; protein N-acetylglucosaminyltransferase activity
GO:97363; protein O-GlcNAc transferase activity
Hide GO terms

Homologs of OGT in Model Organisms

Caenorhabditis elegans
ogt-1
Danio rerio
ogt.2
Drosophila melanogaster
sxc
Mus musculus
Ogt
Rattus norvegicus
Ogt

External links

OMIM
300255
Ensembl
ENSG00000147162
Entrez Gene
8473
UniGene
405410
1000 Genomes
1000 Genomes
HPRD
GenAtlas
OGT
GeneCards
OGT