Cell Senescence Entries for PARK7

Cell Types
Endothelial progenitor
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Han et al. (2018) DJ-1 Alleviates Angiotensin II-Induced Endothelial Progenitor Cell Damage by Activating the PPARγ/HO-1 Pathway. J Cell Biochem 119(1)392-400 (PubMed)

PARK7 Gene Information

HGNC symbol
PARK7 
Aliases
DJ-1; DJ1; GATD2 
Common name
Parkinsonism associated deglycase 
Entrez Id
11315
Description
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].

PARK7 Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6914; autophagy
GO:6954; inflammatory response
GO:98869; cellular oxidant detoxification
GO:7338; single fertilization
GO:7005; mitochondrion organization
GO:50821; protein stabilization
GO:31334; positive regulation of protein-containing complex assembly
GO:51897; positive regulation of protein kinase B signaling
GO:50727; regulation of inflammatory response
GO:32091; negative regulation of protein binding
GO:45944; positive regulation of transcription by RNA polymerase II
GO:70301; cellular response to hydrogen peroxide
GO:1903206; negative regulation of hydrogen peroxide-induced cell death
GO:2001237; negative regulation of extrinsic apoptotic signaling pathway
GO:42593; glucose homeostasis
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:34599; cellular response to oxidative stress
GO:1901215; negative regulation of neuron death
GO:60548; negative regulation of cell death
GO:43523; regulation of neuron apoptotic process
GO:1902236; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:110095; cellular detoxification of aldehyde
GO:10628; positive regulation of gene expression
GO:10629; negative regulation of gene expression
GO:43524; negative regulation of neuron apoptotic process
GO:1903202; negative regulation of oxidative stress-induced cell death
GO:1903377; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903599; positive regulation of autophagy of mitochondrion
GO:6517; protein deglycosylation
GO:1903427; negative regulation of reactive oxygen species biosynthetic process
GO:16570; histone modification
GO:51444; negative regulation of ubiquitin-protein transferase activity
GO:31397; negative regulation of protein ubiquitination
GO:43066; negative regulation of apoptotic process
GO:32148; activation of protein kinase B activity
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:60765; regulation of androgen receptor signaling pathway
GO:30073; insulin secretion
GO:2000825; positive regulation of androgen receptor activity
GO:1905259; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
GO:51881; regulation of mitochondrial membrane potential
GO:1903208; negative regulation of hydrogen peroxide-induced neuron death
GO:1903094; negative regulation of protein K48-linked deubiquitination
GO:2000157; negative regulation of ubiquitin-specific protease activity
GO:10273; detoxification of copper ion
GO:1933; negative regulation of protein phosphorylation
GO:35065; regulation of histone acetylation
GO:2866; positive regulation of acute inflammatory response to antigenic stimulus
GO:6469; negative regulation of protein kinase activity
GO:7265; Ras protein signal transduction
GO:9438; methylglyoxal metabolic process
GO:19249; lactate biosynthetic process
GO:32435; negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:32757; positive regulation of interleukin-8 production
GO:33182; regulation of histone ubiquitination
GO:33234; negative regulation of protein sumoylation
GO:33864; positive regulation of NAD(P)H oxidase activity
GO:36471; cellular response to glyoxal
GO:36526; peptidyl-cysteine deglycation
GO:36527; peptidyl-arginine deglycation
GO:36528; peptidyl-lysine deglycation
GO:36529; protein deglycation, glyoxal removal
GO:36530; protein deglycation, methylglyoxal removal
GO:36531; glutathione deglycation
GO:42743; hydrogen peroxide metabolic process
GO:46295; glycolate biosynthetic process
GO:46826; negative regulation of protein export from nucleus
GO:50787; detoxification of mercury ion
GO:61727; methylglyoxal catabolic process to lactate
GO:106044; guanine deglycation
GO:106045; guanine deglycation, methylglyoxal removal
GO:106046; guanine deglycation, glyoxal removal
GO:140041; cellular detoxification of methylglyoxal
GO:1900182; positive regulation of protein localization to nucleus
GO:1901671; positive regulation of superoxide dismutase activity
GO:1901984; negative regulation of protein acetylation
GO:1902903; regulation of supramolecular fiber organization
GO:1902958; positive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903073; negative regulation of death-inducing signaling complex assembly
GO:1903122; negative regulation of TRAIL-activated apoptotic signaling pathway
GO:1903168; positive regulation of pyrroline-5-carboxylate reductase activity
GO:1903178; positive regulation of tyrosine 3-monooxygenase activity
GO:1903181; positive regulation of dopamine biosynthetic process
GO:1903189; glyoxal metabolic process
GO:1903190; glyoxal catabolic process
GO:1903197; positive regulation of L-dopa biosynthetic process
GO:1903200; positive regulation of L-dopa decarboxylase activity
GO:1903384; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
GO:2000679; positive regulation of transcription regulatory region DNA binding
GO:2001268; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:1963; synaptic transmission, dopaminergic
GO:8344; adult locomotory behavior
GO:34614; cellular response to reactive oxygen species
GO:42177; negative regulation of protein catabolic process
GO:42542; response to hydrogen peroxide
GO:51583; dopamine uptake involved in synaptic transmission
GO:51899; membrane depolarization
GO:60081; membrane hyperpolarization
GO:70994; detection of oxidative stress
GO:1902177; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1903204; negative regulation of oxidative stress-induced neuron death
GO:1903428; positive regulation of reactive oxygen species biosynthetic process
GO:2000277; positive regulation of oxidative phosphorylation uncoupler activity
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5783; endoplasmic reticulum
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:98793; presynapse
GO:45121; membrane raft
GO:45202; synapse
GO:70062; extracellular exosome
GO:5912; adherens junction
GO:48471; perinuclear region of cytoplasm
GO:785; chromatin
GO:30424; axon
GO:16605; PML body
GO:5758; mitochondrial intermembrane space
GO:5759; mitochondrial matrix
GO:43005; neuron projection
GO:44297; cell body
Function: GO:3723; RNA binding
GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:3729; mRNA binding
GO:5102; signaling receptor binding
GO:42802; identical protein binding
GO:45296; cadherin binding
GO:5507; copper ion binding
GO:45340; mercury ion binding
GO:19900; kinase binding
GO:19899; enzyme binding
GO:44877; protein-containing complex binding
GO:1990381; ubiquitin-specific protease binding
GO:140297; DNA-binding transcription factor binding
GO:97110; scaffold protein binding
GO:44390; ubiquitin-like protein conjugating enzyme binding
GO:3713; transcription coactivator activity
GO:16532; superoxide dismutase copper chaperone activity
GO:16684; oxidoreductase activity, acting on peroxide as acceptor
GO:19955; cytokine binding
GO:36470; tyrosine 3-monooxygenase activator activity
GO:36478; L-dopa decarboxylase activator activity
GO:36524; protein deglycase activity
GO:44388; small protein activating enzyme binding
GO:50681; androgen receptor binding
GO:1903135; cupric ion binding
GO:1903136; cuprous ion binding
GO:1990422; glyoxalase (glycolic acid-forming) activity
GO:19826; oxygen sensor activity
GO:51920; peroxiredoxin activity
Hide GO terms

Homologs of PARK7 in Model Organisms

Caenorhabditis elegans
djr-1.2
Danio rerio
park7
Drosophila melanogaster
dj-1beta
Mus musculus
Park7
Rattus norvegicus
Park7
Schizosaccharomyces pombe
SPAC22E12.03c

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as dj-1beta
LongevityMap
  • This gene is present as PARK7

External links

OMIM
602533
Ensembl
ENSG00000116288
Entrez Gene
11315
UniGene
419640
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PARK7
GeneCards
PARK7