The PATZ1 gene and its putative association with human ageing

Cell Senescence Entries for PATZ1

Cell Types: Umbilical vein endothelial
Cell Lines: Primary cell
Cancer Cell?: No
Method: Knockdown, Overexpression
Type of senescence: Unclear
Senescence Effect: Inhibits
Primary Reference: Cho et al. (2012) POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway. Cell Death Differ 19(4)703-12 (PubMed)

PATZ1 Gene Information

HGNC symbol: PATZ1
Aliases: dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; ZSG
Common name: POZ/BTB and AT hook containing zinc finger 1
Entrez Id: 23598
Description: The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008].

PATZ1 Ontologies

Gene Ontology

Process:

GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:7283; spermatogenesis
GO:8584; male gonad development
GO:10468; regulation of gene expression
GO:10596; negative regulation of endothelial cell migration
GO:30217; T cell differentiation
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:6357; regulation of transcription by RNA polymerase II

Cellular component:

GO:5634; nucleus
GO:5654; nucleoplasm

Function:

GO:46872; metal ion binding
GO:3677; DNA binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3682; chromatin binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding

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Homologs of PATZ1 in Model Organisms

Danio rerio: patz1
Mus musculus: Patz1
Rattus norvegicus: Patz1

Cell Senescence Entries for PATZ1

PATZ1 Gene Information

PATZ1 Ontologies

Homologs of PATZ1 in Model Organisms

External links