Cell Senescence Entries for PAX8

Cell Types
Thyroid carcinoma
Cell Lines
K1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Li et al. (2012) PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein. Oncogene 30(48)4824-34 (PubMed)

PAX8 Gene Information

HGNC symbol
PAX8 
Aliases
 
Common name
paired box 8 
Entrez Id
7849
Description
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010].

PAX8 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:1822; kidney development
GO:6351; transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:38194; thyroid-stimulating hormone signaling pathway
GO:42981; regulation of apoptotic process
GO:48856; anatomical structure development
GO:30878; thyroid gland development
GO:9653; anatomical structure morphogenesis
GO:1823; mesonephros development
GO:42472; inner ear morphogenesis
GO:7417; central nervous system development
GO:90190; positive regulation of branching involved in ureteric bud morphogenesis
GO:1658; branching involved in ureteric bud morphogenesis
GO:2000611; positive regulation of thyroid hormone generation
GO:3337; mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:71371; cellular response to gonadotropin stimulus
GO:72207; metanephric epithelium development
GO:72284; metanephric S-shaped body morphogenesis
GO:1655; urogenital system development
GO:48793; pronephros development
GO:72289; metanephric nephron tubule formation
GO:39003; pronephric field specification
GO:72108; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:72221; metanephric distal convoluted tubule development
GO:72305; negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
GO:72307; regulation of metanephric nephron tubule epithelial cell differentiation
GO:1900212; negative regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:1900215; negative regulation of apoptotic process involved in metanephric collecting duct development
GO:1900218; negative regulation of apoptotic process involved in metanephric nephron tubule development
GO:2000594; positive regulation of metanephric DCT cell differentiation
GO:71599; otic vesicle development
GO:72278; metanephric comma-shaped body morphogenesis
GO:2000612; regulation of thyroid-stimulating hormone secretion
GO:1656; metanephros development
GO:3281; ventricular septum development
GO:6790; sulfur compound metabolic process
GO:10667; negative regulation of cardiac muscle cell apoptotic process
GO:72050; S-shaped body morphogenesis
GO:72073; kidney epithelium development
GO:72164; mesonephric tubule development
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:4996; thyroid-stimulating hormone receptor activity
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
Hide GO terms

Homologs of PAX8 in Model Organisms

Danio rerio
pax8
Drosophila melanogaster
sv
Mus musculus
Pax8
Rattus norvegicus
Pax8

External links

OMIM
167415
Ensembl
ENSG00000125618
Entrez Gene
7849
UniGene
469728
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PAX8
GeneCards
PAX8