Cell Senescence Entries for PBRM1

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Lee et al. (2017) BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21. Oncotarget 7(15)19134-46 (PubMed)

PBRM1 Gene Information

HGNC symbol
PBRM1 
Aliases
BAF180; PB1; SMARCH1 
Common name
polybromo 1 
Entrez Id
55193
Description
This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012].

PBRM1 Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:6338; chromatin remodeling
GO:8285; negative regulation of cell population proliferation
GO:6357; regulation of transcription by RNA polymerase II
GO:278; mitotic cell cycle
GO:2000045; regulation of G1/S transition of mitotic cell cycle
GO:2000781; positive regulation of double-strand break repair
GO:30071; regulation of mitotic metaphase/anaphase transition
GO:45582; positive regulation of T cell differentiation
GO:45597; positive regulation of cell differentiation
GO:45663; positive regulation of myoblast differentiation
GO:70316; regulation of G0 to G1 transition
GO:2000819; regulation of nucleotide-excision repair
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:228; nuclear chromosome
GO:16586; RSC-type complex
GO:785; chromatin
GO:16514; SWI/SNF complex
GO:776; kinetochore
GO:16363; nuclear matrix
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:3682; chromatin binding
Hide GO terms

Homologs of PBRM1 in Model Organisms

Caenorhabditis elegans
pbrm-1
Danio rerio
uncharacterized_E7F8
Drosophila melanogaster
polybromo
Mus musculus
Pbrm1
Rattus norvegicus
Pbrm1

External links

OMIM
606083
Ensembl
ENSG00000163939
Entrez Gene
55193
UniGene
734413
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PBRM1
GeneCards
PBRM1