Cell Senescence Entries for PDCD11
- Cell Types
- Breast cancer
- Cell Lines
- MCF-7
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced, Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Nishimura et al. (2015) Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation. Cell Rep 10(8)1310-23 (PubMed)
PDCD11 Gene Information
- HGNC symbol
- PDCD11
- Aliases
- ALG-4; KIAA0185; NFBP; RRP5
- Common name
- programmed cell death 11
- Entrez Id
- 22984
- Description
- PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008].
PDCD11 Ontologies
- Gene Ontology
-
Process: GO:6396; RNA processing
GO:6364; rRNA processing
Cellular component: GO:5634; nucleus
GO:5730; nucleolus
GO:32040; small-subunit processome
GO:5654; nucleoplasm
GO:5829; cytosol
Hide GO termsFunction: GO:3676; nucleic acid binding
GO:5515; protein binding
GO:3723; RNA binding
GO:51059; NF-kappaB binding
Homologs of PDCD11 in Model Organisms
- Caenorhabditis elegans
- let-716
- Danio rerio
- pdcd11
- Drosophila melanogaster
- CG5728
- Mus musculus
- Pdcd11
- Rattus norvegicus
- Pdcd11
- Saccharomyces cerevisiae
- RRP5
- Schizosaccharomyces pombe
- rrp5
External links
- OMIM
- 612333
- Ensembl
- ENSG00000148843
- Entrez Gene
- 22984
- UniGene
- 239499
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PDCD11
- GeneCards
- PDCD11