Cell Senescence Entries for PDPK1

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

PDPK1 Gene Information

HGNC symbol
PDPK1 
Aliases
PDK1 
Common name
3-phosphoinositide dependent protein kinase 1 
Entrez Id
5170
Description

PDPK1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:46777; protein autophosphorylation
GO:35556; intracellular signal transduction
GO:18105; peptidyl-serine phosphorylation
GO:97191; extrinsic apoptotic signaling pathway
GO:45766; positive regulation of angiogenesis
GO:6469; negative regulation of protein kinase activity
GO:30036; actin cytoskeleton organization
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:7173; epidermal growth factor receptor signaling pathway
GO:10518; positive regulation of phospholipase activity
GO:16477; cell migration
GO:18107; peptidyl-threonine phosphorylation
GO:19722; calcium-mediated signaling
GO:32148; activation of protein kinase B activity
GO:32869; cellular response to insulin stimulus
GO:43122; regulation of I-kappaB kinase/NF-kappaB signaling
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:51281; positive regulation of release of sequestered calcium ion into cytosol
GO:71364; cellular response to epidermal growth factor stimulus
GO:1903078; positive regulation of protein localization to plasma membrane
GO:1903672; positive regulation of sprouting angiogenesis
GO:1905564; positive regulation of vascular endothelial cell proliferation
GO:2000352; negative regulation of endothelial cell apoptotic process
GO:3323; type B pancreatic cell development
GO:6972; hyperosmotic response
GO:10594; regulation of endothelial cell migration
GO:10667; negative regulation of cardiac muscle cell apoptotic process
GO:34122; negative regulation of toll-like receptor signaling pathway
GO:43304; regulation of mast cell degranulation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:5925; focal adhesion
GO:30054; cell junction
GO:42995; cell projection
GO:14069; postsynaptic density
GO:31410; cytoplasmic vesicle
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4676; 3-phosphoinositide-dependent protein kinase activity
GO:16004; phospholipase activator activity
GO:43274; phospholipase binding
Hide GO terms

Homologs of PDPK1 in Model Organisms

Danio rerio
pdpk1b
Mus musculus
Pdpk1
Rattus norvegicus
Pdpk1

In other databases

GenAge human genes
  • This gene is present as PDPK1
LongevityMap
  • This gene is present as PDPK1

External links

OMIM
605213
Ensembl
ENSG00000140992
Entrez Gene
5170
UniGene
459691
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PDPK1
GeneCards
PDPK1