Cell Senescence Entries for PEA15
- Cell Types
- Melanoma
- Cell Lines
- SK-MEL-28
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced, Replicative
- Senescence Effect
- Induces
- Primary Reference
- Wajapeyee et al. (2008) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132(3)363-74 (PubMed)
PEA15 Gene Information
- HGNC symbol
- PEA15
- Aliases
- HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; PED; PED-PEA15; PED/PEA15
- Common name
- proliferation and apoptosis adaptor protein 15
- Entrez Id
- 8682
- Description
- This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
PEA15 Ontologies
- Gene Ontology
-
Process: GO:6915; apoptotic process
GO:42981; regulation of apoptotic process
GO:8643; carbohydrate transport
GO:165; MAPK cascade
GO:43278; response to morphine
GO:1902042; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:46325; negative regulation of glucose import
Cellular component: GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5875; microtubule associated complex
Hide GO termsFunction: GO:5515; protein binding
Homologs of PEA15 in Model Organisms
In other databases
- CellAge gene expression
- This gene is present as PEA15
External links
- OMIM
- 603434
- Ensembl
- ENSG00000162734
- Entrez Gene
- 8682
- UniGene
- 517216
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PEA15
- GeneCards
- PEA15