Cell Senescence Entries for PELP1
- Cell Types
- Colorectal cancer
- Cell Lines
- HT-29
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Ning et al. (2015) PELP1 suppression inhibits colorectal cancer through c-Src downregulation. Oxid Med Cell Longev 2014(2)193523 (PubMed)
PELP1 Gene Information
- HGNC symbol
- PELP1
- Aliases
- MNAR
- Common name
- proline, glutamate and leucine rich protein 1
- Entrez Id
- 27043
- Description
- This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
PELP1 Ontologies
- Gene Ontology
-
Process: GO:45944; positive regulation of transcription by RNA polymerase II
GO:71391; cellular response to estrogen stimulus
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:71339; MLL1 complex
GO:35327; transcriptionally active chromatin
Hide GO termsFunction: GO:3723; RNA binding
GO:5515; protein binding
GO:3682; chromatin binding
GO:47485; protein N-terminus binding
GO:51117; ATPase binding
GO:32183; SUMO binding
Homologs of PELP1 in Model Organisms
- Danio rerio
- uncharacterized_F1RE
- Mus musculus
- Pelp1
- Rattus norvegicus
- Pelp1
External links
- OMIM
- 609455
- Ensembl
- ENSG00000141456
- Entrez Gene
- 27043
- UniGene
- 744899
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PELP1
- GeneCards
- PELP1