Cell Senescence Entries for PES1
- Cell Types
- Breast cancer
- Cell Lines
- MCF-7
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced, Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Nishimura et al. (2015) Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation. Cell Rep 10(8)1310-23 (PubMed)
PES1 Gene Information
- HGNC symbol
- PES1
- Aliases
- NOP7; PES
- Common name
- pescadillo ribosomal biogenesis factor 1
- Entrez Id
- 23481
- Description
- This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011].
PES1 Ontologies
- Gene Ontology
-
Process: GO:42254; ribosome biogenesis
GO:6364; rRNA processing
GO:51726; regulation of cell cycle
GO:463; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:466; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:42273; ribosomal large subunit biogenesis
GO:8283; cell population proliferation
Cellular component: GO:5634; nucleus
GO:16020; membrane
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:5694; chromosome
GO:43229; intracellular organelle
GO:30687; preribosome, large subunit precursor
GO:70545; PeBoW complex
Hide GO termsFunction: GO:3723; RNA binding
GO:5515; protein binding
GO:43021; ribonucleoprotein complex binding
Homologs of PES1 in Model Organisms
- Caenorhabditis elegans
- lpd-7
- Danio rerio
- pes
- Drosophila melanogaster
- CG4364
- Mus musculus
- Pes1
- Rattus norvegicus
- Pes1
- Saccharomyces cerevisiae
- NOP7
- Schizosaccharomyces pombe
- ppp1
External links
- OMIM
- 605819
- Ensembl
- ENSG00000100029
- Entrez Gene
- 23481
- UniGene
- 517543
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PES1
- GeneCards
- PES1