Cell Senescence Entries for PEX19

Cell Types
Osteosarcoma
Cell Lines
U2OS
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Widodo et al. (2007) Stress chaperones, mortalin, and pex19p mediate 5-aza-2' deoxycytidine-induced senescence of cancer cells by DNA methylation-independent pathway. J Gerontol A Biol Sci Med Sci 62(3)246-55 (PubMed)

PEX19 Gene Information

HGNC symbol
PEX19 
Aliases
D1S2223E; HK33; PMP1; PMPI; PXF; PXMP1 
Common name
peroxisomal biogenesis factor 19 
Entrez Id
5824
Description
This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010].

PEX19 Ontologies

Gene Ontology
Process: GO:7031; peroxisome organization
GO:50821; protein stabilization
GO:16559; peroxisome fission
GO:6625; protein targeting to peroxisome
GO:61077; chaperone-mediated protein folding
GO:45046; protein import into peroxisome membrane
GO:72663; establishment of protein localization to peroxisome
GO:1900131; negative regulation of lipid binding
GO:16557; peroxisome membrane biogenesis
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5777; peroxisome
GO:5778; peroxisomal membrane
GO:31526; brush border membrane
Function: GO:5515; protein binding
GO:47485; protein N-terminus binding
GO:51117; ATPase binding
GO:33328; peroxisome membrane targeting sequence binding
GO:36105; peroxisome membrane class-1 targeting sequence binding
GO:140597; protein carrier activity
Hide GO terms

Homologs of PEX19 in Model Organisms

Caenorhabditis elegans
prx-19
Danio rerio
pex19
Drosophila melanogaster
Pex19
Mus musculus
Pex19
Rattus norvegicus
LOC100911356

External links

OMIM
600279
Ensembl
ENSG00000162735
Entrez Gene
5824
UniGene
517232
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PEX19
GeneCards
PEX19