Cell Senescence Entries for PHB

Cell Types
Breast cancer
Cell Lines
MCF-7, T47D
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Rastogi et al. (2006) Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes. Mol Cell Biol 26(11)4161-71 (PubMed)

PHB Gene Information

HGNC symbol
PHB 
Aliases
PHB1 
Common name
prohibitin 
Entrez Id
5245
Description
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

PHB Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:6355; regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:45893; positive regulation of transcription, DNA-templated
GO:71897; DNA biosynthetic process
GO:42981; regulation of apoptotic process
GO:51897; positive regulation of protein kinase B signaling
GO:7005; mitochondrion organization
GO:50821; protein stabilization
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:42113; B cell activation
GO:1901224; positive regulation of NIK/NF-kappaB signaling
GO:122; negative regulation of transcription by RNA polymerase II
GO:46718; viral entry into host cell
GO:42177; negative regulation of protein catabolic process
GO:70373; negative regulation of ERK1 and ERK2 cascade
GO:8285; negative regulation of cell population proliferation
GO:48661; positive regulation of smooth muscle cell proliferation
GO:10944; negative regulation of transcription by competitive promoter binding
GO:32740; positive regulation of interleukin-17 production
GO:30308; negative regulation of cell growth
GO:140374; antiviral innate immune response
GO:10942; positive regulation of cell death
GO:1649; osteoblast differentiation
GO:60766; negative regulation of androgen receptor signaling pathway
GO:10628; positive regulation of gene expression
GO:39529; RIG-I signaling pathway
GO:7202; activation of phospholipase C activity
GO:45745; positive regulation of G protein-coupled receptor signaling pathway
GO:2639; positive regulation of immunoglobulin production
GO:23035; CD40 signaling pathway
GO:50847; progesterone receptor signaling pathway
GO:71354; cellular response to interleukin-6
GO:16575; histone deacetylation
GO:44830; modulation by host of viral RNA genome replication
GO:45917; positive regulation of complement activation
GO:72538; T-helper 17 type immune response
GO:1990051; activation of protein kinase C activity
GO:2000323; negative regulation of glucocorticoid receptor signaling pathway
Cellular component: GO:16020; membrane
GO:5737; cytoplasm
GO:5634; nucleus
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5654; nucleoplasm
GO:5769; early endosome
GO:9986; cell surface
GO:70062; extracellular exosome
GO:5887; integral component of plasma membrane
GO:35632; mitochondrial prohibitin complex
Function: GO:5515; protein binding
GO:8022; protein C-terminus binding
GO:46982; protein heterodimerization activity
GO:19899; enzyme binding
GO:3714; transcription corepressor activity
GO:42826; histone deacetylase binding
GO:1851; complement component C3b binding
GO:1850; complement component C3a binding
GO:31871; proteinase activated receptor binding
Hide GO terms

Homologs of PHB in Model Organisms

Caenorhabditis elegans
phb-1
Danio rerio
phb
Drosophila melanogaster
l(2)37Cc
Mus musculus
Phb
Rattus norvegicus
Phb
Saccharomyces cerevisiae
PHB1
Schizosaccharomyces pombe
phb1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as PHB1
  • A homolog of this gene for Caenorhabditis elegans is present as phb-1

External links

OMIM
176705
Ensembl
ENSG00000167085
Entrez Gene
5245
UniGene
514303
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PHB
GeneCards
PHB