Cell Senescence Entries for PHB2

Cell Types
Human epithelial
Cell Lines
MCF-7
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Taniguchi et al. (2018) Prohibitin-2 is a novel regulator of p21WAF1/CIP1 induced by depletion of γ-glutamylcyclotransferase. Biochem Biophys Res Commun 496(1)218-224 (PubMed)

PHB2 Gene Information

HGNC symbol
PHB2 
Aliases
Bap37; BCAP37; p22; REA 
Common name
prohibitin 2 
Entrez Id
11331
Description

PHB2 Ontologies

Gene Ontology
Process: GO:6396; RNA processing
GO:43066; negative regulation of apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:7005; mitochondrion organization
GO:50821; protein stabilization
GO:16477; cell migration
GO:423; mitophagy
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:42113; B cell activation
GO:6606; protein import into nucleus
GO:1901224; positive regulation of NIK/NF-kappaB signaling
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:31536; positive regulation of exit from mitosis
GO:140374; antiviral innate immune response
GO:7062; sister chromatid cohesion
GO:39529; RIG-I signaling pathway
GO:7202; activation of phospholipase C activity
GO:2639; positive regulation of immunoglobulin production
GO:23035; CD40 signaling pathway
GO:1990051; activation of protein kinase C activity
GO:1902808; positive regulation of cell cycle G1/S phase transition
GO:1900208; regulation of cardiolipin metabolic process
GO:9611; response to wounding
GO:33147; negative regulation of intracellular estrogen receptor signaling pathway
GO:33600; negative regulation of mammary gland epithelial cell proliferation
GO:60744; mammary gland branching involved in thelarche
GO:60749; mammary gland alveolus development
GO:60762; regulation of branching involved in mammary gland duct morphogenesis
GO:71300; cellular response to retinoic acid
GO:71456; cellular response to hypoxia
GO:1904959; regulation of cytochrome-c oxidase activity
Cellular component: GO:5730; nucleolus
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:32991; protein-containing complex
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5741; mitochondrial outer membrane
GO:71944; cell periphery
GO:9986; cell surface
GO:16363; nuclear matrix
GO:35632; mitochondrial prohibitin complex
GO:14069; postsynaptic density
GO:30424; axon
GO:48786; presynaptic active zone
GO:98800; inner mitochondrial membrane protein complex
GO:98978; glutamatergic synapse
GO:98982; GABA-ergic synapse
Function: GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:30331; estrogen receptor binding
GO:8022; protein C-terminus binding
GO:47485; protein N-terminus binding
GO:46982; protein heterodimerization activity
GO:46625; sphingolipid binding
GO:33218; amide binding
Hide GO terms

Homologs of PHB2 in Model Organisms

Caenorhabditis elegans
phb-2
Danio rerio
phb2
Drosophila melanogaster
l(2)03709
Mus musculus
Phb2
Rattus norvegicus
Phb2
Saccharomyces cerevisiae
PHB2
Schizosaccharomyces pombe
phb2

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as PHB2
  • A homolog of this gene for Caenorhabditis elegans is present as phb-2
CellAge gene expression
  • This gene is present as PHB2

External links

OMIM
610704
Ensembl
ENSG00000215021
Entrez Gene
11331
UniGene
504620
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PHB2
GeneCards
PHB2