Cell Senescence Entries for PHGDH

Cell Types
Lung cancer
Cell Lines
NT2/D1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Sharif et al. (2019) Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells. Cell Death Dis 9(10)990 (PubMed)

PHGDH Gene Information

HGNC symbol
PHGDH 
Aliases
PDG; PGDH; SERA 
Common name
phosphoglycerate dehydrogenase 
Entrez Id
26227
Description
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011].

PHGDH Ontologies

Gene Ontology
Process: GO:6564; L-serine biosynthetic process
GO:8652; cellular amino acid biosynthetic process
GO:22900; electron transport chain
GO:7420; brain development
GO:6541; glutamine metabolic process
GO:6544; glycine metabolic process
GO:6563; L-serine metabolic process
GO:6566; threonine metabolic process
GO:9448; gamma-aminobutyric acid metabolic process
GO:10468; regulation of gene expression
GO:19530; taurine metabolic process
GO:21510; spinal cord development
GO:21782; glial cell development
GO:21915; neural tube development
GO:22008; neurogenesis
GO:31175; neuron projection development
GO:70314; G1 to G0 transition
Cellular component: GO:5829; cytosol
GO:70062; extracellular exosome
Function: GO:16491; oxidoreductase activity
GO:16616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:51287; NAD binding
GO:30060; L-malate dehydrogenase activity
GO:4617; phosphoglycerate dehydrogenase activity
GO:9055; electron transfer activity
Hide GO terms

Homologs of PHGDH in Model Organisms

Caenorhabditis elegans
C31C9.2
Danio rerio
phgdh
Drosophila melanogaster
CG6287
Mus musculus
Phgdh
Rattus norvegicus
Phgdh
Saccharomyces cerevisiae
SER33
Schizosaccharomyces pombe
SPCC364.07

In other databases

CellAge gene expression
  • This gene is present as PHGDH

External links

OMIM
606879
Ensembl
ENSG00000092621
Entrez Gene
26227
UniGene
487296
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PHGDH
GeneCards
PHGDH