Cell Senescence Entries for PIK3CA

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Mutation
Type of senescence
Oncogene-induced
Senescence Effect
Unclear
Primary Reference
Astle et al. (2012) AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy. Oncogene 31(15)1949-62 (PubMed)

PIK3CA Gene Information

HGNC symbol
PIK3CA 
Aliases
PI3K 
Common name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha 
Entrez Id
5290
Description
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016].

PIK3CA Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:6468; protein phosphorylation
GO:6629; lipid metabolic process
GO:46854; phosphatidylinositol phosphate biosynthetic process
GO:30168; platelet activation
GO:48015; phosphatidylinositol-mediated signaling
GO:1525; angiogenesis
GO:32147; activation of protein kinase activity
GO:14065; phosphatidylinositol 3-kinase signaling
GO:6909; phagocytosis
GO:16477; cell migration
GO:51897; positive regulation of protein kinase B signaling
GO:36092; phosphatidylinositol-3-phosphate biosynthetic process
GO:50852; T cell receptor signaling pathway
GO:35994; response to muscle stretch
GO:43542; endothelial cell migration
GO:30036; actin cytoskeleton organization
GO:7173; epidermal growth factor receptor signaling pathway
GO:10592; positive regulation of lamellipodium assembly
GO:55119; relaxation of cardiac muscle
GO:2000811; negative regulation of anoikis
GO:31295; T cell costimulation
GO:86003; cardiac muscle cell contraction
GO:1944; vasculature development
GO:38084; vascular endothelial growth factor signaling pathway
GO:38028; insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:60048; cardiac muscle contraction
GO:16242; negative regulation of macroautophagy
GO:43276; anoikis
GO:1889; liver development
GO:1932; regulation of protein phosphorylation
GO:6006; glucose metabolic process
GO:10468; regulation of gene expression
GO:10629; negative regulation of gene expression
GO:14823; response to activity
GO:14870; response to muscle inactivity
GO:30835; negative regulation of actin filament depolymerization
GO:32008; positive regulation of TOR signaling
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:40014; regulation of multicellular organism growth
GO:43201; response to leucine
GO:43457; regulation of cellular respiration
GO:43491; protein kinase B signaling
GO:43524; negative regulation of neuron apoptotic process
GO:44029; hypomethylation of CpG island
GO:48661; positive regulation of smooth muscle cell proliferation
GO:60612; adipose tissue development
GO:71333; cellular response to glucose stimulus
GO:71464; cellular response to hydrostatic pressure
GO:71548; response to dexamethasone
GO:97009; energy homeostasis
GO:110053; regulation of actin filament organization
GO:1903544; response to butyrate
GO:2000270; negative regulation of fibroblast apoptotic process
GO:2000653; regulation of genetic imprinting
GO:6661; phosphatidylinositol biosynthetic process
Cellular component: GO:5737; cytoplasm
GO:5886; plasma membrane
GO:5942; phosphatidylinositol 3-kinase complex
GO:16020; membrane
GO:5829; cytosol
GO:48471; perinuclear region of cytoplasm
GO:5943; phosphatidylinositol 3-kinase complex, class IA
GO:14704; intercalated disc
GO:5944; phosphatidylinositol 3-kinase complex, class IB
GO:30027; lamellipodium
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:46934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:52812; phosphatidylinositol-3,4-bisphosphate 5-kinase activity
GO:35004; phosphatidylinositol 3-kinase activity
GO:16303; 1-phosphatidylinositol-3-kinase activity
GO:35005; 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:52742; phosphatidylinositol kinase activity
GO:30295; protein kinase activator activity
GO:43560; insulin receptor substrate binding
Hide GO terms

Homologs of PIK3CA in Model Organisms

Danio rerio
LOC100334726
Mus musculus
Pik3ca
Rattus norvegicus
Pik3ca

In other databases

GenAge human genes
  • This gene is present as PIK3CA
LongevityMap
  • This gene is present as PIK3CA

External links

OMIM
171834
Ensembl
ENSG00000121879
Entrez Gene
5290
UniGene
715194
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PIK3CA
GeneCards
PIK3CA