Cell Senescence Entries for PIM1

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
2BS, BJ, WI-38
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Induces
Primary Reference
Jin et al. (2015) PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation. Aging Cell 13(5)879-89 (PubMed)

PIM1 Gene Information

HGNC symbol
PIM1 
Aliases
PIM 
Common name
Pim-1 proto-oncogene, serine/threonine kinase 
Entrez Id
5292
Description
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011].

PIM1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:45893; positive regulation of transcription, DNA-templated
GO:50821; protein stabilization
GO:90336; positive regulation of brown fat cell differentiation
GO:1902033; regulation of hematopoietic stem cell proliferation
GO:46777; protein autophosphorylation
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:7275; multicellular organism development
GO:60045; positive regulation of cardiac muscle cell proliferation
GO:22898; regulation of transmembrane transporter activity
GO:70561; vitamin D receptor signaling pathway
GO:1905062; positive regulation of cardioblast proliferation
GO:1990748; cellular detoxification
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:5886; plasma membrane
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:30145; manganese ion binding
GO:8134; transcription factor binding
GO:43024; ribosomal small subunit binding
Hide GO terms

Homologs of PIM1 in Model Organisms

Danio rerio
pim1
Mus musculus
Pim1
Rattus norvegicus
Pim1

In other databases

CellAge gene expression
  • This gene is present as PIM1

External links

OMIM
164960
Ensembl
ENSG00000137193
Entrez Gene
5292
UniGene
81170
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PIM1
GeneCards
PIM1