Cell Senescence Entries for PIN1

Cell Types
Vascular smooth muscle
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Lv et al. (2018) Downregulation of Pin1 in human atherosclerosis and its association with vascular smooth muscle cell senescence. J Vasc Surg 68(3)873-883.e5 (PubMed)

PIN1 Gene Information

HGNC symbol
PIN1 
Aliases
dod 
Common name
peptidylprolyl cis/trans isomerase, NIMA-interacting 1 
Entrez Id
5300
Description
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011].

PIN1 Ontologies

Gene Ontology
Process: GO:413; protein peptidyl-prolyl isomerization
GO:7049; cell cycle
GO:1666; response to hypoxia
GO:31647; regulation of protein stability
GO:43547; positive regulation of GTPase activity
GO:70373; negative regulation of ERK1 and ERK2 cascade
GO:50821; protein stabilization
GO:32092; positive regulation of protein binding
GO:7088; regulation of mitotic nuclear division
GO:45944; positive regulation of transcription by RNA polymerase II
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:51443; positive regulation of ubiquitin-protein transferase activity
GO:1902430; negative regulation of amyloid-beta formation
GO:32091; negative regulation of protein binding
GO:10468; regulation of gene expression
GO:50808; synapse organization
GO:1934; positive regulation of protein phosphorylation
GO:60393; regulation of pathway-restricted SMAD protein phosphorylation
GO:1932; regulation of protein phosphorylation
GO:35307; positive regulation of protein dephosphorylation
GO:32465; regulation of cytokinesis
GO:30182; neuron differentiation
GO:42177; negative regulation of protein catabolic process
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:1900180; regulation of protein localization to nucleus
GO:2000146; negative regulation of cell motility
Cellular component: GO:5654; nucleoplasm
GO:5829; cytosol
GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:36064; ciliary basal body
GO:98978; glutamatergic synapse
GO:30496; midbody
GO:99524; postsynaptic cytosol
Function: GO:16853; isomerase activity
GO:3755; peptidyl-prolyl cis-trans isomerase activity
GO:5515; protein binding
GO:48156; tau protein binding
GO:32794; GTPase activating protein binding
GO:8013; beta-catenin binding
GO:31434; mitogen-activated protein kinase kinase binding
GO:50815; phosphoserine residue binding
GO:50816; phosphothreonine residue binding
GO:3774; cytoskeletal motor activity
GO:16859; cis-trans isomerase activity
GO:51219; phosphoprotein binding
Hide GO terms

Homologs of PIN1 in Model Organisms

Caenorhabditis elegans
pinn-1
Danio rerio
pin1
Drosophila melanogaster
dod
Mus musculus
Pin1
Rattus norvegicus
LOC364561
Saccharomyces cerevisiae
ESS1
Schizosaccharomyces pombe
pin1

In other databases

GenAge human genes
  • This gene is present as PIN1

External links

OMIM
601052
Ensembl
ENSG00000127445
Entrez Gene
5300
UniGene
465849
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PIN1
GeneCards
PIN1