Cell Senescence Entries for PINX1

Cell Types
Colorectal cancer
Cell Lines
SW480
Cancer Cell?
Yes
Method
Mutation, Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Zhang et al. (2015) PinX1 without the G-patch motif suppresses proliferation, induces senescence, but does not inhibit telomerase activity in colorectal cancer SW480 cells. Oncol Rep 32(1)286-92 (PubMed)

PINX1 Gene Information

HGNC symbol
PINX1 
Aliases
FLJ20565; Gno1; LPTL; LPTS; MGC8850; Pxr1 
Common name
PIN2 (TERF1) interacting telomerase inhibitor 1 
Entrez Id
54984
Description

PINX1 Ontologies

Gene Ontology
Process: GO:8285; negative regulation of cell population proliferation
GO:31647; regulation of protein stability
GO:1904751; positive regulation of protein localization to nucleolus
GO:31397; negative regulation of protein ubiquitination
GO:7080; mitotic metaphase plate congression
GO:70198; protein localization to chromosome, telomeric region
GO:1904357; negative regulation of telomere maintenance via telomere lengthening
GO:51974; negative regulation of telomerase activity
GO:32211; negative regulation of telomere maintenance via telomerase
GO:1902570; protein localization to nucleolus
GO:7004; telomere maintenance via telomerase
GO:10972; negative regulation of G2/M transition of mitotic cell cycle
GO:51972; regulation of telomerase activity
GO:90069; regulation of ribosome biogenesis
GO:1904744; positive regulation of telomeric DNA binding
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5739; mitochondrion
GO:5694; chromosome
GO:775; chromosome, centromeric region
GO:5819; spindle
GO:776; kinetochore
GO:228; nuclear chromosome
Function: GO:3676; nucleic acid binding
GO:5515; protein binding
GO:44877; protein-containing complex binding
GO:10521; telomerase inhibitor activity
GO:70034; telomerase RNA binding
GO:3677; DNA binding
Hide GO terms

Homologs of PINX1 in Model Organisms

Caenorhabditis elegans
CELE_T23G7.3
Danio rerio
pinx1
Mus musculus
Pinx1
Rattus norvegicus
Pinx1
Saccharomyces cerevisiae
PXR1
Schizosaccharomyces pombe
pxr1

External links

OMIM
606505
Ensembl
ENSG00000254093
Entrez Gene
54984
UniGene
490991
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PINX1
GeneCards
PINX1